Printer-Friendly Version
Variant | Association | Phenotype | Sample Information | Author |
---|---|---|---|---|
rs3842727 rs6356 | Allelic:ns Genotypic:ns Haplotypic: ns | Suicide attempts | Etnicity: German | Giegling, 2009 |
Cases: 111 suicide attempters, M=43; F= 68; mean age 39.2 ± 13.6 | ||||
Controls: 289 subjects M=123 F=166; mean age 45.2 ± 14.9 | ||||
|
Allelic: ns |
Suicide & suicide attempts |
Ethnicity: German |
Giegling, 2008 |
Cases: 167 suicide attempters (M:58, F:109; mean age, 39.89 ± 13.89; 60 patients classified as violent and 101 as impulsive) |
||||
Cases: 92 Caucasian suicide completers (M:53, F:39; mean age 51.8 ± 18.5) | ||||
Controls: unrelated German volunteers without personal or family histories of neuropsychiatric disorders (F:174, M:138; mean age, 45.01 ± 14.92) |
||||
Notes: excluded stratification using genomic control; no association with personality traits; stratified for violence, impulsiveness, completion versus attempt |
||||
Intron 1 tetranucleotide repeat
|
Allelic: ns | Suicidal behaviour severity | Cases: 336 (F:62%) bipolar patients from 305 nuclear families (mean age: 35.36± 10.37 SD), including 267 patients with histories of suicide ideas or attempts | De Luca, 2008 |
Notes: suicidality assessed quantitatively and coded as follows: 0 = absence of suicide/death thoughts, 1 = thoughts of death, 2 = suicide ideation, 3 = suicide plan, 4 = suicide attempt; marginal association between TH and severe suicidal behavior |
||||
|
Allelic: ns |
Suicide | Ethnicity: Japanese |
Hattori, 2006 |
Cases: 189 suicide victims (F: 62, mean age ± SD, 47.9±17.6) | ||||
Controls: 187 unrelated volunteers (F:61; mean age ± SD, 44.7 ± 14.9) | ||||
PstI |
Genotypic: ns | Suicide attempts | Ethnicity: English, Caucasian | Ho, 2000 |
Cases: bipolar (M:58, F:73) & unipolar patients (M:53, F:86) | ||||
Tetranucleotide | Genotypic: ns | Notes: in the unipolar sample, the promoter locus associated with psychotic symptoms; uncorrected for multiple testing | ||
THK 1-5
|
Genotypic: +, THK3, p=.0023, patients with adjustment disorders | Suicide attempts |
Ethnicity: Caucasian, mostly Swedish |
Persson, 1997 |
Cases: suicide attempters: F:76,M:42; mean age: 41 |
||||
Nonpsychiatric controls: F:33,M:45; mean age: 39 | ||||
Notes: Bonferroni corrected |
Notes: += positive,significant; -, =negative,significant; ns=nonsignificant; F=females; M=males
Variant | Association | Phenotype | Sample Information | Author |
---|---|---|---|---|
3’ UTR VNTR in exon 15 |
Genotypic: ns |
Suicide attempts | Ethnicity: White Italian Caucasian |
Gerra 2005 |
Heroin-dependent patients: 104 males (mean age:33.7±12.3), including 22 suicide attempters | ||||
125 healthy male volunteers: mean age:35.7±13.9 | ||||
Notes: The 9-repeat allele confers increased susceptibility to antisocial violent behaviour and aggressiveness in heroin-dependent males |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
Exon III 48bp repeat | Allelic: ns Genotypic:ns |
Suicide attempts | Cases: 69 recent adolescent attempters: F:58%; mean age ± SD: 17.7 ± 3.2; Ethnicity: 35 Ashkenazi Jewish | Zalsman, 2004 |
Historical controls: N:167; Ethnicity: 109 Ashkenazi Jewish | ||||
Notes: homozygosity for all allele lengths associated with depression severity; Bonferroni-adjusted analyses | ||||
Exon III 48bp repeat | Allelic: ns Genotypic: ns |
Suicide attempts | Cases: 165 (F:108) suicide attempters: mean age ± SD: 41±17; Ethnicity: Caucasian (77% Swedish, European) |
Persson, 1999 |
Controls: n:99 (F:35); mean age ± SD: 38 ±6; Ethnicity: Caucasian (80% Swedish European) | ||||
Notes: not significant after stratification by diagnosis |
Notes: += positive,significant; - =negative,significant; ns=nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
141CDel/Ins (rs1799732) TaqIA (rs1800497) |
Genotypic: 141CIns, +, χ 2 = 8.429, d.f. = 2, p = 0.015 Logistic regression analysis: –141C Ins/Del genotypes (p = 0.014; OR, 1.95;
TaqIA,A2, +,χ2 = 6.76, d.f. = Allelic: 141CIns, +, p = 0.011 OR=1.85, 95%CI: 1.16– TaqIA,A2 +, p=0.017 1.56 95% CI: 1.09–2.25 Haplotypic: ns
|
Suicide attempts | Ethnicity: Japanese
|
Suda, 2009 |
Cases: 120 subjects: (F=62,5%) Suicide attempters
|
||||
Controls:123 unrelated healthy volunteers (F=65,9%) | ||||
141CDel/Ins | Allelic: +, 141CDel, 1.29, 95%CI 1.02-1.64 | Suicide attempts or suicidal ideas | Ethnicity: Caucasian, German | Johann, 2005 |
Cases: 1126 (F:24%) alcoholic inpatients, including 209 suicidal patients; mean age: 43.3±9.7 | ||||
Controls: 232 individuals without axis I diagnosis or prior psychiatric treatment | ||||
Notes: Bonferroni corrected; this allele also associated with family history of alcoholism | ||||
Promoter locus |
Genotypic: ns |
Suicide attempts | Ethnicity: English, Caucasian |
Ho, 2000 |
Cases: Bipolar (M:58, F: 73 female) and unipolar patients (M:53, F: 86) | ||||
Notes: in the unipolar sample, the promoter locus associated with history of psychotic symptoms; uncorrected for multiple testing | ||||
Exon 8 A/G | Genotypic: +,AA, 1.67, 95%CI 1.1-2.5 | Suicide attempts | Ethnicity: Caucasian, German |
Finckh, 1997 |
Cases: 283 alcoholic patients (F:50); mean age: 43±9 | ||||
Non-alcoholic controls: 146 (F:76); mean age: 54±6 | ||||
Notes: AA genotype associated with anxiety and depresion but not with alcoholism |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
(CA)n |
Allelic: ns | Suicidal behaviour severity | Cases: 336 (F:62%) bipolar patients from 305 nuclear families (mean age: 35.36± 10.37 SD), including 267 patients with suicide ideas or attempts | De Luca, 2007 |
Notes: suicidality assessed quantitatively and coded as follows: 0 = absence of suicide/death thoughts, 1 = thoughts of death, 2 = suicide ideation, 3 = suicide plan, 4 = suicide attempt |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Sample Information | Author |
---|---|---|---|---|
rs1451371 rs1470750 rs998850 | Allelic:ns Genotypic:ns Haplotypic: ns | Suicide attempts | Etnicity: German | Giegling, 2009 |
Cases: 111 suicide attempters, M=43; F= 68; mean age 39.2 ± 13.6 | ||||
Controls: 289 subjects M=123 F=166; mean age 45.2 ± 14.9 | ||||
rs1451371, rs1470750 rs998850 |
Allelic: ns |
Suicide & suicide attempts |
Ethnicity: German |
Giegling, 2007 |
Cases: 167 suicide attempters (M:58, F:109; mean age, 39.89 ± 13.89), including 60 violent and 101 impulsive attempters |
||||
Cases: 92 Caucasian suicide completers (M:53, F:39; mean age: 51.8 ± 18.5) | ||||
Controls: unrelated German volunteers without personal/ family history of neuropsychiatric disorders (F:174, M:138; mean age: 45.01±14.92) |
||||
Notes: excluded stratification using genomic control; no association with personality traits; stratified for violence, impulsiveness, completion versus attempt; marginal associations with suicide, violence, anger, and aggression |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
Val158Met
|
Allelic: ns | Suicidal behaviour severity | Cases: 336 (F:62%) bipolar patients from 305 nuclear families (mean age: 35.36± 10.37 SD), including 267 patients with histories of suicide ideas or attempts | De Luca, 2008 |
Notes: suicidality assessed quantitatively and coded as follows: 0 = absence of suicide/death thoughts, 1 = thoughts of death, 2 = suicide ideation, 3 = suicide plan, 4 = suicide attempt; marginal association between TH & severe suicidal behaviour |
||||
287AG | Allelic: ns |
Suicide attempts | Sample: schizophrenic patients (n:270) including 92 suicide attempters [F:24, mean age: 42.6±9.7] and nonattempters [mean age:40.6±11.2] | De Luca, 2006 |
Val/Met | Allelic: ns | Notes: investigated one MAOA and three COMT variants; analyses also stratified by sex and violence of the attempt method | ||
3'UTR C Ins/Del | Allelic: ns | |||
Haplotypic: ns | ||||
Epistasis with MAOA: ns | ||||
Val108/158Met | Allelic: ns | Suicide attempts | Sample: 336 bipolar patients (F:62%) including 86 suicide attempters; mean age: 35.36±10.37 | De Luca, 2005 |
Notes: Analyses based on TDT; suicidality also assessed quantitatively | ||||
Epistatic interaction with MAOA: ns | ||||
Val108/158Met | Allelic:+, L, OR 1.57, 95% CI 1.04-2.38, relative to controls | Violent suicide attempts |
Ethnicity: German | Rujescu, 2003 |
Suicide attempters: F:96, M:53; mean age:40±13, including 55 violent attempters | ||||
Allelic:+, L, OR 1.7, 95% CI 1.07-2.79, relative to nonviolent attempters | Community controls: F:179, M:149; mean age: 46±15 | |||
Genotypic: +, LL, OR=2.12, 95% CI 1.18-3.83, relative to controls | Notes: LL carriers expressed anger outwardly and HH carriers more inwardly, controlling for age & sex | |||
Genotypic: +, LL, OR=2.35, 95% CI 1.15-4.82, relative to nonviolent attempters | ||||
Val158Met | Allelic: ns Genotypic: ns |
Suicide attempts | Ethnicity: Chinese, Taiwan | Liou, 2001 |
Cases: schizophrenic patients: F:104,M:94; mean age: 37.8±12.1; including 62 suicide attempters | ||||
Healthy volunteer controls: F:91,M:97; mean age: 38.6±16.6 | ||||
Notes: not associated with schizophrenia | ||||
Val108/158Met | Allelic:+,Met, p=.05, men Genotypic: +, Met-, p=.017, men |
Violent suicide attempts |
Ethnicity: Finnish nonSaami sample: n:94 (F:10, mean age: 41.8, 57 suicide attempters) and USA sample (White, 4 Hispanic): n: 54 (F:21, mean age: 42.9, 27 suicide attempters) | Nolan, 2000 |
Cases: schizophrenic/ schizoaffective attempters and nonattempters | ||||
Allelic:+, Met, p=.008, men Genotypic: +, Met-, p=.028, men |
Suicide attempts | Notes: association found in the combined samples and in the Finnish subsample | ||
L/H | Allelic: ns Genotypic: ns |
Suicide attempts | Ethnicity: Japanese | Ohara, 1998 |
Cases: mood-disordered patients [M:60; F:55; 12 suicide attempters; mean age: 48.5±16.3] | ||||
135 healthy controls | ||||
Notes: positive association of LL genotype with depressive disorders [OR=2.19; 95%CI 1.19-4.03] | ||||
Val108/158Met | Allelic: ns Genotypic: +,Val/Met, OR 1.98 95% 1.16-3.37, males |
Suicide | Cases: suicide completers: M:112, mean age: 48.68±16.9; F:51, mean age:47.12±19.8 | Ono, 2004 |
Controls: M:114, mean age:45.33±15.5; F:55, mean age: 48.9±18.7 | ||||
Notes: trend toward deviation from HW equilibrium in male completers | ||||
Val108/158Met | Genotypic: ns | Suicide risk | Cases: patients at high risk for suicide: F:32,M:19; mean age:38±15; Caucasian (n:41), African-American (n:6), and Hispanic, Indian, and Asian (n:4) | Russ, 2000 |
Race-matched controls: F:28,M:23; mean age: 41±13 | ||||
Notes: Bonferroni corrected |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Sample Information | Author |
---|---|---|---|---|
uVNTR |
Allelic: ns |
Suicide attempts | Cases: 270 schizophrenic patients: 92 (F:24) suicide attempters (mean age: 42.6±9.7) and 178 nonattempters (mean age: 40.6±11.2) |
De Luca, 2006 |
Notes: Investigated one MAO and three COMT variants; also stratified by sex and violence of suicide attempt |
||||
uVNTR
|
Allelic: ns |
Violent suicide attempts |
Ethnicity: West European, Caucasian |
|
Hospitalized suicide attempters: F:512, M:226; mean age: 38.08 ± 14.12 |
||||
CAn | Allelic: ns |
Suicide attempts | Non-psychiatric controls without first-degree family history of suicide attempts: F:68, M:154; mean age: 44.25±13.26 | |
Notes: CAn is in LD with uVNTR | ||||
uVNTR T941G |
Allelic: ns Haplotypic: ns Epistatic: ns |
Suicide attempts | Sample: 336 bipolar patients (F:62%) including 86 suicide attempters; mean age:35.36±10.37 |
De Luca, 2005 |
Notes: analyses based on TDT; no epistasis with COMT Val108/158 Met | ||||
uVNTR |
Allelic: ns |
Suicide attempts | Ethnicity: white Caucasian, Italian |
Gerra, 2004 |
Cases: heroin–dependent males: n:104, mean age: 33.7±12.3 |
||||
Controls: age- and sex-matched healthy volunteers: n:95; mean age: 35.7±13.9 | ||||
Notes: this variant confers increased susceptibility to antisocial violent behavior and aggressiveness | ||||
uVNTR |
Allelic: ns |
Suicide attempts | Cases: mood-disordered patients: F:377, M:286; mean age: 37.6 ±12.9; Caucasian: 68.8%, African-Americans 16.6%, Asian, Hispanic and "'other" 14.6% |
Huang, 2004 |
Nonpsychiatric controls with comparable ethnic composition: F:47, M:56; mean age: 38.8 ±15.3 | ||||
Notes: lower expression allele associated with history of child abuse before 15 years of age and higher impulsivity in males | ||||
CAn |
Genotypic: ns |
Suicide attempts | Ethnicity: English, Caucasian |
Ho, 2000 |
VNTR | Genotypic:+, VNTR, +, p=0.029, bipolar patients | Cases: Bipolar (M:58, F: 73) and unipolar patients (M:53, F: 86) | ||
Fnu4HI | Genotypic:+, 11, P=0.0162 , female bipolar patients | Notes: VNTR’s association with history of suicide attempts stronger in females; uncorrected for multiple testing | ||
VNTR |
Allelic: ns Genotypic: ns |
Suicide attempts | Ethnicity: Japanese |
Kunugi, 1999 |
Patients with bipolar disorder (M:59, F:102; mean age: 47.6±13.7) or unipolar (F:61, M:37; mean age: 54.5±16.4), including 55 suicide attempters | ||||
Controls: M:132,F:126; mean age: 31.8.6±12.3 | ||||
Notes: no association with mood disorders | ||||
EcoRV | Allelic: +,high-activity allele, OR:3.1, 95% CI 1.3-7.5, males |
Suicide | Ethnicity: Caucasian, Hungary |
Du, 2002 |
Depressed suicide completers: F:11, M:33 mean age: 47.9±14.4 | ||||
Controls who died of non-suicide-related causes: F:28, M:64 mean age: 57.5±13.6 | ||||
Notes: Bonferroni-corrected | ||||
uVNTR | Allelic: ns Genotypic: ns |
Suicide | Ethnicity: Japanese |
Ono, 2002 |
Cases: suicides: M: 107, mean age: 48.4 ±16.6; F: 48, mean age: 47.6± 19.9 | ||||
Healthy volunteers: M: 109; mean age: 45.1± 15.3, F: 53; mean age: 48.4±18.8 |
Notes: += positive,significant; -, =negative,significant; ns= nonsignificant; F=females; M=males