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Variant | Association | Phenotype | Notes | Author |
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rs3750625 | Allelic: ns Genotypic: ns |
Suicide | Ethnicity: Japanese |
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C1291G | Allelic:+,C, OR=1.96 CI95% 1.15-3.32, in females Genotypic:+,CG, p=.043, in females |
Cases: suicide completers: M: 124 (mean age:49.2±16.9) and F: 60 (mean age: 45.7±19.0) | ||
Controls: M: 134 (mean age: 41.9 ±16.1) & F:87 (mean age: 45.1±16.4) | ||||
Haplotypic:+, CC, p=.032, in females | Notes: N251K and insertion/deletion polymorphism not found in the sample; associations remained positive in female violent suicide attempts. | |||
G1800T | Allelic: ns Genotypic: ns |
Suicide | Ethnicity: French Canadian |
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C1291G | Allelic: ns Genotypic: ns |
Cases:male suicide completers: n:110, mean age:32.20±9.38 | ||
G261A | Allelic: ns Genotypic: ns |
Male controls: n:130, mean age:34.00±10.56 | ||
N251K | Allelic: ns Genotypic: ns |
Notes: N251K allele seen exclusively in suicides (n=3); Genotypes did not differ in impulsivity, aggressivity, or TCI temperament dimensions | ||
C1291G | Allelic: ns Genotypic: ns |
Suicide attempts | Ethnicity: Japanese | Ohara, 1998 |
Cases: mood-disordered patients (F:55, M:48; including 11 suicide attempters) | ||||
Volunteer controls: F:62, M:52; mean age: 37.7±15.9 | ||||
Notes: no association with mood disorders; Bonferroni-adjusted analyses |
Notes: += positive,significant; -, =negative,significant; ns= nonsignificant; F=females; M=males;
Variant | Association | Phenotype | Notes | Author |
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G1287A | Allelic: ns Genotypic: ns |
Suicidal ideas | Ethnicity: Caucasian |
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Cases: mood-disordered patients: F:64, M:41; mean age:39.5±8.94 | ||||
Race-matched controls without medical or psychtric illness: M:33, F:41; mean age:34.8±10.7 | ||||
Notes: no asociation with major depression |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Sample Information | Author |
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|
Allelic: ns |
Suicide & suicide attempts |
Ethnicity: German |
Giegling, 2007 |
Cases: 167 suicide attempters (M:58, F:109; mean age, 39.89 ± 13.89; 60 patients classified as violent and 101 as impulsive) |
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Cases: 92 Caucasian suicide completers (M:53, F:39; mean age 51.8 ± 18.5) | ||||
Controls: unrelated German volunteers without personal or family histories of neuropsychiatric disorders (F:174, M:138; mean age, 45.01 ± 14.92) |
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Notes: excluded stratification using genomic control; no association with personality traits; stratified for violence, impulsiveness, completion versus attempt |
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Intron 1 tetranucleotide repeat
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Allelic: ns | Suicidal behaviour severity | Cases: 336 (F:62%) bipolar patients from 305 nuclear families (mean age: 35.36± 10.37 SD), including 267 patients with histories of suicide ideas or attempts | De Luca, 2007 |
Notes: suicidality assessed quantitatively and coded as follows: 0 = absence of suicide/death thoughts, 1 = thoughts of death, 2 = suicide ideation, 3 = suicide plan, 4 = suicide attempt; marginal association between TH and severe suicidal behavior |
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|
Allelic: ns |
Suicide | Ethnicity: Japanese |
Hattori, 2006 |
Cases: 189 suicide victims (F: 62, mean age ± SD, 47.9±17.6) | ||||
Controls: 187 unrelated volunteers (F:61; mean age ± SD, 44.7 ± 14.9) | ||||
PstI |
Genotypic: ns | Suicide attempts | Ethnicity: English, Caucasian | Ho, 2000 |
Cases: bipolar (M:58, F:73) & unipolar patients (M:53, F:86) | ||||
Tetranucleotide | Genotypic: ns | Notes: in the unipolar sample, the promoter locus associated with psychotic symptoms; uncorrected for multiple testing | ||
THK 1-5
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Genotypic: +, THK3, p=.0023, patients with adjustment disorders | Suicide attempts |
Ethnicity: Caucasian, mostly Swedish |
Persson, 1997 |
Cases: suicide attempters: F:76,M:42; mean age: 41 |
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Nonpsychiatric controls: F:33,M:45; mean age: 39 | ||||
Notes: Bonferroni corrected |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
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COMT: allele Val158Met
TPH1: allele A218C
MAOA: allele u-VNTR male |
Genotypic; s, COMT Met, p=.003 trait anger ; p=.041 anger out TPH1 A218C, p=.029 anger control MAOA u-VNTR, p=.041 state anger |
Suicide Attempters | Ethnicity: Caucasian, French | Perroud, 2010 |
Cases: 895 suicide attempters (F: 619; 39.6 ± 12.9) | ||||
Notes: A significant correlation was found between sexual abuse and the Met allele, distinguishing it as the major epigenetic factor out of all other environmental variables | ||||
Val158Met | Allelic: ns Genotypic: ns |
Mood disoders | Ethnicity: Caucasian | Zalsman, 2008 |
Healthy volunteers: 119 | ||||
Mood disorders subject: 486 | ||||
Notes: CSF metabolites were assayed in a sub-sample of mood disorder patients (N=111) | ||||
No association between genotype and mood disorder diagnosis or with reported history of suicide attempt in mood disorder subjects No association between genotype and lethality, or method of suicide attempt, or with aggressive/impulsive traits. |
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Val158Met
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Allelic: ns | Suicidal behaviour severity | Cases: 336 (F:62%) bipolar patients from 305 nuclear families (mean age: 35.36± 10.37 SD), including 267 patients with histories of suicide ideas or attempts | De Luca, 2007 |
Notes: suicidality assessed quantitatively and coded as follows: 0 = absence of suicide/death thoughts, 1 = thoughts of death, 2 = suicide ideation, 3 = suicide plan, 4 = suicide attempt; marginal association between TH & severe suicidal behaviour |
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287AG | Allelic: ns |
Suicide attempts | Sample: schizophrenic patients (n:270) including 92 suicide attempters [F:24, mean age: 42.6±9.7] and nonattempters [mean age:40.6±11.2] | De Luca, 2006 |
Val/Met | Allelic: ns | Notes: investigated one MAOA and three COMT variants; analyses also stratified by sex and violence of the attempt method | ||
3'UTR C Ins/Del | Allelic: ns | |||
Haplotypic: ns | ||||
Epistasis with MAOA: ns | ||||
Val108/158Met | Allelic: ns | Suicide attempts | Sample: 336 bipolar patients (F:62%) including 86 suicide attempters; mean age: 35.36±10.37 | De Luca, 2005 |
Notes: Analyses based on TDT; suicidality also assessed quantitatively | ||||
Epistatic interaction with MAOA: ns | ||||
Val108/158Met | Allelic:+, L, OR 1.57, 95% CI 1.04-2.38, relative to controls | Violent suicide attempts |
Ethnicity: German | Rujescu, 2003 |
Suicide attempters: F:96, M:53; mean age:40±13, including 55 violent attempters | ||||
Allelic:+, L, OR 1.7, 95% CI 1.07-2.79, relative to nonviolent attempters | Community controls: F:179, M:149; mean age: 46±15 | |||
Genotypic: +, LL, OR=2.12, 95% CI 1.18-3.83, relative to controls | Notes: LL carriers expressed anger outwardly and HH carriers more inwardly, controlling for age & sex | |||
Genotypic: +, LL, OR=2.35, 95% CI 1.15-4.82, relative to nonviolent attempters | ||||
Val158Met | Allelic: ns Genotypic: ns |
Suicide attempts | Ethnicity: Chinese, Taiwan | Liou, 2001 |
Cases: schizophrenic patients: F:104,M:94; mean age: 37.8±12.1; including 62 suicide attempters | ||||
Healthy volunteer controls: F:91,M:97; mean age: 38.6±16.6 | ||||
Notes: not associated with schizophrenia | ||||
Val108/158Met | Allelic:+,Met, p=.05, men Genotypic: +, Met-, p=.017, men |
Violent suicide attempts |
Ethnicity: Finnish nonSaami sample: n:94 (F:10, mean age: 41.8, 57 suicide attempters) and USA sample (White, 4 Hispanic): n: 54 (F:21, mean age: 42.9, 27 suicide attempters) | Nolan, 2000 |
Cases: schizophrenic/ schizoaffective attempters and nonattempters | ||||
Allelic:+, Met, p=.008, men Genotypic: +, Met-, p=.028, men |
Suicide attempts | Notes: association found in the combined samples and in the Finnish subsample | ||
L/H | Allelic: ns Genotypic: ns |
Suicide attempts | Ethnicity: Japanese | Ohara, 1998 |
Cases: mood-disordered patients [M:60; F:55; 12 suicide attempters; mean age: 48.5±16.3] | ||||
135 healthy controls | ||||
Notes: positive association of LL genotype with depressive disorders [OR=2.19; 95%CI 1.19-4.03] | ||||
Val108/158Met | Allelic: ns Genotypic: +,Val/Met, OR 1.98 95% 1.16-3.37, males |
Suicide | Cases: suicide completers: M:112, mean age: 48.68±16.9; F:51, mean age:47.12±19.8 | Ono, 2004 |
Controls: M:114, mean age:45.33±15.5; F:55, mean age: 48.9±18.7 | ||||
Notes: trend toward deviation from HW equilibrium in male completers | ||||
Val108/158Met | Genotypic: ns | Suicide risk | Cases: patients at high risk for suicide: F:32,M:19; mean age:38±15; Caucasian (n:41), African-American (n:6), and Hispanic, Indian, and Asian (n:4) | Russ, 2000 |
Race-matched controls: F:28,M:23; mean age: 41±13 | ||||
Notes: Bonferroni corrected |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Sample Information | Author |
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uVNTR |
Allelic: ns |
Suicide attempts | Cases: 270 schizophrenic patients: 92 (F:24) suicide attempters (mean age: 42.6±9.7) and 178 nonattempters (mean age: 40.6±11.2) |
De Luca, 2006 |
Notes: Investigated one MAO and three COMT variants; also stratified by sex and violence of suicide attempt |
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uVNTR
|
Allelic: ns |
Violent suicide attempts |
Ethnicity: West European, Caucasian |
|
Hospitalized suicide attempters: F:512, M:226; mean age: 38.08 ± 14.12 |
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CAn | Allelic: ns |
Suicide attempts | Non-psychiatric controls without first-degree family history of suicide attempts: F:68, M:154; mean age: 44.25±13.26 | |
Notes: CAn is in LD with uVNTR | ||||
uVNTR T941G |
Allelic: ns Haplotypic: ns Epistatic: ns |
Suicide attempts | Sample: 336 bipolar patients (F:62%) including 86 suicide attempters; mean age:35.36±10.37 |
De Luca, 2005 |
Notes: analyses based on TDT; no epistasis with COMT Val108/158 Met | ||||
uVNTR |
Allelic: ns |
Suicide attempts | Ethnicity: white Caucasian, Italian |
Gerra, 2004 |
Cases: heroin–dependent males: n:104, mean age: 33.7±12.3 |
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Controls: age- and sex-matched healthy volunteers: n:95; mean age: 35.7±13.9 | ||||
Notes: this variant confers increased susceptibility to antisocial violent behavior and aggressiveness | ||||
uVNTR |
Allelic: ns |
Suicide attempts | Cases: mood-disordered patients: F:377, M:286; mean age: 37.6 ±12.9; Caucasian: 68.8%, African-Americans 16.6%, Asian, Hispanic and "'other" 14.6% |
Huang, 2004 |
Nonpsychiatric controls with comparable ethnic composition: F:47, M:56; mean age: 38.8 ±15.3 | ||||
Notes: lower expression allele associated with history of child abuse before 15 years of age and higher impulsivity in males | ||||
CAn |
Genotypic: ns |
Suicide attempts | Ethnicity: English, Caucasian |
Ho, 2000 |
VNTR | Genotypic:+, VNTR, +, p=0.029, bipolar patients | Cases: Bipolar (M:58, F: 73) and unipolar patients (M:53, F: 86) | ||
Fnu4HI | Genotypic:+, 11, P=0.0162 , female bipolar patients | Notes: VNTR’s association with history of suicide attempts stronger in females; uncorrected for multiple testing | ||
VNTR |
Allelic: ns Genotypic: ns |
Suicide attempts | Ethnicity: Japanese |
Kunugi, 1999 |
Patients with bipolar disorder (M:59, F:102; mean age: 47.6±13.7) or unipolar (F:61, M:37; mean age: 54.5±16.4), including 55 suicide attempters | ||||
Controls: M:132,F:126; mean age: 31.8.6±12.3 | ||||
Notes: no association with mood disorders | ||||
EcoRV | Allelic: +,high-activity allele, OR:3.1, 95% CI 1.3-7.5, males |
Suicide | Ethnicity: Caucasian, Hungary |
Du, 2002 |
Depressed suicide completers: F:11, M:33 mean age: 47.9±14.4 | ||||
Controls who died of non-suicide-related causes: F:28, M:64 mean age: 57.5±13.6 | ||||
Notes: Bonferroni-corrected | ||||
uVNTR | Allelic: ns Genotypic: ns |
Suicide | Ethnicity: Japanese |
Ono, 2002 |
Cases: suicides: M: 107, mean age: 48.4 ±16.6; F: 48, mean age: 47.6± 19.9 | ||||
Healthy volunteers: M: 109; mean age: 45.1± 15.3, F: 53; mean age: 48.4±18.8 |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males