Variant |
Association |
Phenotype |
Sample Information |
Author |
rs1451371 rs1470750 rs998850 |
Allelic:ns Genotypic:ns Haplotypic: ns |
Suicide attempts |
Etnicity: German |
Giegling, 2009 |
Cases: 111 suicide attempters, M=43; F= 68; mean age 39.2 ± 13.6 |
Controls: 289 subjects M=123 F=166; mean age 45.2 ± 14.9 |
rs1451371, rs1470750, rs998850 |
Allelic: ns
Genotypic: ns Haplotypic: ns |
Suicide & suicide attempts |
Ethnicity: German |
Giegling, 2007 |
Cases: 167 suicide attempters (M:58, F:109; mean age, 39.89 ± 13.89), including 60 violent and 101 impulsive attempters |
Cases: 92 Caucasian suicide completers (M:53, F:39; mean age: 51.8 ± 18.5) |
Controls: unrelated German volunteers without personal/ family history of neuropsychiatric disorders (F:174, M:138; mean age: 45.01±14.92) |
Notes: excluded stratification using genomic control; no association with personality traits; stratified for violence, impulsiveness, completion versus attempt; marginal associations with suicide, violence, anger, and aggression |
Variant |
Association |
Phenotype |
Notes |
Author |
Val158Met
|
Allelic: ns |
Suicidal behaviour severity |
Cases: 336 (F:62%) bipolar patients from 305 nuclear families (mean age: 35.36± 10.37 SD), including 267 patients with histories of suicide ideas or attempts |
De Luca, 2007 |
Notes: suicidality assessed a quantitatively and coded as follows: 0 = absence of suicide/death thoughts, 1 = thoughts of death, 2 = suicide ideation, 3 = suicide plan, 4 = suicide attempt |
287AG |
Allelic: ns
|
Suicide attempts |
Sample: schizophrenic patients (n:270): suicide attempters: 92 (F:24), mean age:42.6±9.7; nonattempters: mean age:40.6±11.2 |
De Luca, 2006 |
Val/Met |
Allelic: ns |
Notes: Investigated one MAO and three COMT variants; analyses also stratified by sex and violence of attempt method |
3'UTR C Ins/Del |
Allelic: ns |
|
Haplotypic: ns |
Epistatic interaction with MAO's uVNTR: ns |
Val108/158Met |
Allelic: ns |
Suicide attempts |
Sample: 336 bipolar patients (F:62%) including 86 suicide attempters; mean age:35.36±10.37 |
De Luca, 2005 |
Notes: Analyses based on TDT; suicidality also assessed quantitatively |
Epistatic interaction with MAOA: ns |
Val108/158Met |
Allelic:+, L, OR 1.57, 95% CI 1.04-2.38, relative to controls |
Violent suicide attempts |
Ethnicity: German |
Rujescu, 2003 |
Allelic:+, L, OR 1.7, 95% CI 1.07-2.79, relative to nonviolent attempters |
Suicide attempters: F:96, M:53; mean age:40±13; violent attempters:55] |
Genotypic: +, LL, OR=2.12, 95% CI 1.18-3.83, relative to controls |
Community controls: F:179,M:149; mean age: 46±15] |
Genotypic: +, LL, OR=2.35, 95% CI 1.15-4.82, relative to nonviolent attempters |
Notes: LL carriers expressed anger outwardly and HH carriers more inwardly, controlling for age and sex |
Val158Met |
Allelic: ns
Genotypic: ns |
Suicide attempts |
Ethnicity: Chinese, Taiwan; |
Liou, 2001 |
Cases: schizophrenic patients [F:104,M:94; mean age: 37.8±12.1], including 62 suicide attempters |
Healthy volunteer controls: F:91,M:97; mean age: 38.6±16.6 |
Notes: not associated with schizophrenia with or without violence |
Val108/158Met |
Allelic:+,Met, p=.05, men
Genotypic: +, Met-, p=.017, men |
Violent suicide attempts |
Ethnicity: Finnish nonSaami sample: n:94 (F:10, mean age: 41.8, 57 suicide attempters) and USA sample (White, 4 Hispanic): n: 54 (F:21, mean age: 42.9, 27 suicide attempters) |
Nolan, 2000 |
Cases: schizophrenic/ schizoaffective attempters and nonattempters |
Allelic:+, Met, p=.008, men
Genotypic: +, Met-, p=.028, men |
Suicide attempts |
Notes: association found in the combined samples and in the Finnish sample on its own |
L/H |
Allelic: ns
Genotypic: ns |
Suicide attempts |
Ethnicity: Japanese |
Ohara, 1998 |
Cases: 12 mood-disordered patients [M:60, F:55; suicide attempters; mean age:48.5±16.3] |
Healthy controls: N:135 |
Notes: positive association of LL genotype with depressive disorders [p=.012, OR=2.19; 95%CI 1.19-4.03] |
Val108/158Met |
Allelic: ns
Genotypic: -,Val/Val, OR .52 95% .31-.89, males
Genotypic: +,Val/Met, OR 1.98 95% 1.16-3.37, males |
Suicide |
Cases: suicide completers: M:112; mean age:48.68±16.9; F:51; mean age: 47.12±19.8 |
Ono, 2004 |
Controls: M:114; mean age:45.33±15.5; F:55; mean age: 48.9±18.7 |
Notes: trend toward deviation from HW equilibrium in male completers |
Val108/158Met |
Genotypic: ns |
Suicide risk |
Cases: patients at high risk for suicide: F:32,M:19; mean age:38±15; Caucasian (n:41), African-American (n:6), and Hispanic, Indian, and Asian (n:4) |
Russ, 2000 |
Race-matched controls: F:28,M:23; mean age:41±13 |
Notes:Bonferroni corrected |
Variant |
Association |
Phenotype |
Sample Information |
Author |
uVNTR |
Allelic: ns
Epistasis with COMT: ns |
Suicide attempts |
Cases: 270 schizophrenic patients: 92 (F:24) suicide attempters (mean age: 42.6±9.7) and 178 nonattempters (mean age: 40.6±11.2) |
De Luca, 2006 |
Notes: Investigated one MAO and three COMT; also stratified by sex and violence of suicide attempt |
uVNTR
|
Allelic: ns
Genotypic: +,2-3 alleles, OR: 2.17 95% CI 1.08-4.35, males |
Violent
suicide attempts |
Ethnicity: West European, Caucasian |
Courtet, 2005
|
Hospitalized suicide attempters: F:512; M:226; mean age: 38.08 ± 14.12 |
CAn |
Allelic: ns
|
Suicide attempts |
Non-psychiatric controls without first-degree family history of suicide attempts: F:68, M:154; mean age: 44.25±13.26 |
Notes: CAn is in LD with uVNTR |
uVNTR
T941G |
Allelic: ns
Haplotypic: ns
Epistasis with COMT: ns |
Suicide attempts |
Sample: 336 bipolar patients (F:62%) including 86 suicide attempters; mean age:35.36±10.37
|
De Luca, 2005 |
Notes:
analyses based on TDT; No epistasis with COMT Val108/158 Met |
uVNTR |
Allelic: ns |
Suicide attempts |
Ethnicity: white Caucasian, Italian |
Gerra, 2004 |
Heroin –dependent males: n:104; mean age: 33.7±12.3
|
Age- and sex-matched healthy volunteers: n:95; mean age: 35.7±13.9 |
Notes: this variant confers increased susceptibility to antisocial violent behavior and aggressiveness in heroin-dependent males |
uVNTR |
Allelic: ns
Genotypic: ns |
Suicide attempts |
Cases: mood-disordered patients: F:377, M:286; mean age: 37.6 ±12.9; Caucasian: 68.8%; African-Americans 16.6%; Asian, Hispanic and ‘’other" 14.6% |
Huang, 2004 |
Nonpsychiatric controls with comparable ethnic composition: F:47, M:56; mean age: 38.8 ±15.3 |
Notes: lower expression allele associated with history of child abuse before 15 years of age and higher impulsivity in males |
CAn |
ns |
Suicide attempts |
Ethnicity: English, Caucasian |
Ho, 2000 |
VNTR |
Genotypic: +, VNTR, ,p=0.029, bipolar patients |
Cases: bipolar (M:58, F: 73) and unipolar patients (M:53, F: 86) |
Fnu4HI |
Genotypic:+, 11, p=0.0162, female bipolar patients |
Notes: VNTR’s association with suicide attempts stronger in females; uncorrected for multiple testing |
VNTR |
Allelic: ns
Genotypic: ns |
Suicide attempts |
Ethnicity: Japanese |
Kunugi, 1999 |
Patients with bipolar disorder (M:59, F:102; mean age: 47.6±13.7) or unipolar (F:61, M:37; mean age: 54.5±16.4), including 55 suicide attempters |
Controls: M:132; F:126 mean age: 31.8.6±12.3 |
Notes: no association with mood disorders |
EcoRV |
Allelic: +,high-activity allele, OR:3.1, 95% CI 1.3-7.5, males |
Suicide |
Ethnicity: Caucasian, Hungary
|
Du, 2002 |
Depressed suicide completers: F:11; M:33 mean age: 47.9±14.4 |
Controls who died of non-suicide-related causes:
F:28; M:64 mean age: 57.5±13.6 |
Notes: Bonferroni-corrected |
uVNTR |
Allelic: ns
Genotypic: ns |
Suicide |
Ethnicity: Japanese |
Ono, 2002 |
Cases: suicides [M: 107; mean age: 48.4 ±16.6; F: 48; mean age: 47.6± 19.9] |
Healthy volunteers [M: 109; mean age: 45.1± 15.3; F: 53; mean age: 48.4±18.8] |