Gene Candidates

 

 

 

 

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Limbic system-associated membrane protein (LSAMP)
 
Variant Association Phenotype Notes Author
30 tag SNPs

Allelic: ns
Genotypic: ns Haplotypic: ns

Suicide

 

Cases: 288 male suicide victims (mean age: 42.8±13.69, 46 )

Must, 2000
2. 327 healthy male volunteers qirh no psychiatric history or suicide attempts (mean age: 40.5±14.49 )
Notes: four significant allelic associations disappeared after correcting for multiple tests

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

 

Regulator of G-protein signalling 2 (RGS2)

Variant Association Phenotype Notes Author
rs4606 Genotypic: +, CC, χ2=10.47, respectively, p<.05, Prevalence of suicidal ideation Suicidal ideation 607 participants: 35.1% men, 64.9% women; 22.6% ≤ 59 years of age, 77.4% ≥ 60 years of age; 90% white, 3.9% black,
3.9% Hispanic, 1.7% other, 0.5% missing self-report race/ethnicity data
Amstadter, 2009
Genotypic:+,CC, χ2 n=8.28, p<.01 OR=5.30, 95% CI: 1.93-22.96, p<.05 (association with suicidal ideation)

rs2746072

Allelic: +, G, OR 1.4 (1.06–1.86)

Genotypic: ns

Suicide

Ethnicity: Japanese

Cui, 2007

rs4606

Allelic :+,G, 1.5 (1.13–1.98)

Genotypic: +,GG, p=.011

rs2746012

Allelic: ns

Genotypic: ns

Suicide completers: 189 (F:62, 47.8±17.5)

rs3767488

Allelic: ns

Genotypic: ns

Age/sex-matched controls: n:210 (F:71,46.1±18.1)

 

Haplotypic: multiple combinations that include rs4606

Notes: also tested subsample immunoreactivity, finding it higher in the amygdala & BA9

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

P450 System Genes (CYP2D6 and CYP2C19)
 
Variant Association Phenotype Notes Author

CYP2D6: alleles 3,4,5,6 & deletion or multiplication

CYP2D1: alleles 2,3,4


Genotypic: ns

 

Suicide attempts

 

Cases: schizophrenia spectrum disorder patients: n:362 (59% men; mean age 44±9; 178 attempters)

Kobylecki, 2008

Notes: no asociation with substance abuse disorder

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

µ-Opioid Receptor (OPRM1)
 
Variant Association Phenotype Notes Author
A118G (rs1799971) Allelic: ns
Genotypic: -,AG+GG, OR=.63, 95% CI .42-.93

Suicide

 

Ethnicity: Japanese

Hishimoto, 2008
Completed suicides: F:60,mean age: 46.9±19.6; M: 123, mean age: 49.0±16.7

 

Controls: F: 213, mean age: 45.3±17.1; M: 161, mean age: 39.6±15.9

rs1074287

rs12205732

rs2075572

Allelic: ns
Genotypic: ns

 

Haplotypic (A118G,rs1074287, rs12205732): ns

Notes: covaried for sex and age; corrected for multiple tests

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

 

ATP-binding cassette, sub-family G (WHITE), member 1(ABCG1)
 
Variant Association Phenotype Notes Author
G2457A Allelic: ns
Genotypic: ns

Suicide

attempts

Ethnicity: Caucasian [age:18-65]

Rujescu, 2000
1. Original sample: a. inpatients with suicide attempts & psychiatric disorders [F:44; M:26] b.inpatients with uni/bipolar depression [F:35; M:17] c. population controls [F:49; M:48]
2. Replication sample: a. depressed outpatients [F:79; M:25] b. healthy controls [F:27; M:65]
Notes: Original association with affective disorders not replicated

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Spermine/spermidine N1-acetyltransferase gene (SSAT)
 
Variant Association Phenotype Notes Author
rs6151267 Allelic; s, D, p=.01 Suicide with depression vs. Non-suicide with depression Suicide Completers

Ethnicity: French Canadian

Fiori, 2010
Cases: 326 suicide (F: 0; 40.8 ± 13.5 )
Control: 445 non-suicide (F: 0; 40.4 ± 13.5)
Notes: No significant difference between suicide and control, significant difference in frequency between suicide with depression and non-suicide with depression.
SSAT342A

 

Allelic: +,C, OR 2.7 95% CI 1.4-5.3


 

Suicide

 

Ethnicity: French Canadian

Sequiera, 2006

Cases: 181 male suicide completers

80 controls matched by age, sex, ethnicity

Notes: of the 4 examined loci (SSAT460,SSAT495,SSAT624,SSAT342), only SSAT342 sufficiently polymorphic; A allele associated with higher gene expression in BA4 and BA11.

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Manganese superoxide dismutase (MnSOD)

Variant Association Phenotype Notes Author
Ala-9Val Allelic: ns
Genotypic: ns
Suicide attempts Ethnicity: Korean

 

Pae, 2006

Cases: mood disorder patients: n: 141 (M:102)
Unrelated nonpsychiatric controls: n: 106 (M: 51)
Notes: no association with mood disorders

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

PC1 Duarte

Variant Association Phenotype Notes Author
A/D
Genotypic: +, DD, (p<.001)
Suicide Ethnicity: Caucasian

 

Comings, 1979

Cases: Neurological cases (n:276 including 31 suicides)
Non-neurological controls: n:103
Notes: 64.2% of the suicides with depressive, manic-depressive & alcoholic diseases carried the D variant

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Oestrogen receptor 1 (ESR1)

Variant Association Phenotype Notes Author
rs827421 rs1913474 rs1801132 rs722207 rs974276 rs910416

Allelic: ns
Genotypic: ns
Haplottypic: ns

Suicide attempts Etnicity: German Giegling, 2009
Cases: 111 Suicide attempters; 38.7% males, mean age: 39.2+/-13.6
Controls: 289 subjects; 42.6% males, mean age: 45.2+/-14.9

Pvu II

XbaI

Allelic: ns
Genotypic: ns
Suicide attempts Ethnicity: Han Chinese, Taiwan

 

Tsai, 2003

Cases: 154 major depressive patients: F:89; mean age: 46.8±17.4, 46 suicide attempters
226 healthy controls: F:126; Ethnicity: n:109 were Ashkenazi Jewish; mean age: 46.6±16.7
Notes: In females, found PvuII allelic & genotypic differences

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

glycogen synthase kinase 3 (GSK3-B)

Variant Association Phenotype Notes Author
−1727A/T, −50C/T

Genotypic: ns

Allelic:ns

Haplotypic: ns

Suicide attempts

Ethnicity: Korean

Yoon, 2010

Cases: 170 suicidal depressed (F: 92; 40.28 ± 6.83 ), 147 non-suicide depressed (F: 79 39.87 ± 8.14)

Control: 164 (F: 89; 40.33 ± 7.52)

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Angiotensin I converting (peptidyl-dipeptidase A) 1 (ACE)

Variant Association Phenotype Notes Author
I/D

Genotypic: +, II, male suicides vs male control OR = 1.68, CI = 1.15–2.5, p = 0.007

male suicides vs female suicides OR = 2.11, CI = 1.24–3.6, p = 0.005

male suicides vs pooled controls 1.79, CI = 1.24–2.56, p = 0.001

 

Completed suicide Ethnicity: Caucasian Fudalej, 2009
Cases: n=150 (F: 30%) median age: 43
Age- and sex-matched controls: n=165 (F:28.4%)

effect of number of the copies of the ACE I allele on method of suicide in males:

hanging versus not
hanging, OR = 0.36 (CI = 0.17–0.75), pcorrected = 0.048;

jumping from height versus not jumping from
height, OR =17.98 (CI = 2.25–143.51), pcorrected = 0.00003

I/D Allelic: ns
Genotypic: ns
Suicide attempts Ethnicity: Chinese

 

Hong, 2002

Sample: major depressive patients: n:93 (F:51, 51 suicide attempters): mean age: 46.7±18.3]
Notes: no association with major depression nor with antidepressant effects
I/D

Genotype: ns
Allelic:+,I,OR= 1.48 95% CI 1.08 to 2.01, males

Suicide

Ethnicity: Kobe city, Japan descent

Hishimoto 2006

Cases: suicides [M:115, mean age: 47.9± 16.1 years; F:51, mean age: 49.1 ±20.1) ]
Sex/age-matched healthy volunteer controls: [M:115, mean age: 46.7 ±15.9; F:51, mean age: 47.6 ±18.3]
Notes: Bonferroni-corrected; Part of a larger study of 4 four variants in RAS-related genes
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

 

Tyrosine 3-monooxygenase/tryptophan 5 monooxygenase activation protein, epsilon polypeptide (YWHAE)

Variant Association Phenotype Notes Author

T5424C (rs1532976)

Allelic: ns
Genotypic: ns
Suicide Ethnicity: Japanese

 

Yanagi, 2005

Cases: 185 suicides: age mean: 47.7±17.9; F:61

C38340A (rs3752826)

Allelic: ns
Genotypic: ns
359 non-psychiatric controls: F:206; age mean: 42.3±16.3

T55012C (rs9393)

Allelic: ns
Genotypic: ns
Notes: Bonferoni adjusted analyses
  Haplotypic: +, multiple, p=.0005

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Sodium Channel, Voltage-gated, type VIII, Alpha polypeptide (SCN8A)

Variant Association Phenotype Notes Author
rs303802 Allelic: significant in both samples: 1. exploratory step: p1=.008 2. combined sample: p=.005, OR 1.71, 95%CI 1.27-2.34 Suicide attempts Ethnicity: Caucasian, Ukranian, Russian, or East European

Wasserman, 2005

Sample 1 (exploratory analyses): N:77 triplets; mean age: 22.7±6.5; F: 46.8%

Sample 2 (validation analyses): N=190 triplets; mean age: 24.7±7.6; F: 41.1 %
Notes: TDT test; no asociation with major depression

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Sodium channel, voltage-gated, type IX, alpha subunit (SCN9A)

Variant Association Phenotype Notes Author

rs16851799

rs7607967

rs4371369

rs4453709

rs4597545

rs4387806

rs6754031

rs12620053

rs13017637

rs12994338

rs4447616

Genotypic: ns Borderline Personality Disorder Ethnicity: Caucasian Tadić, 2008
Cases:161 well-defined Caucasian Borderline Personality Disorder (BDP)patients M=49,F=112mean age ± SD = 33.2 ± 9.4
Controls: 156, M=46 ,F= 110, mean age ± SD = 33.6 ± 9.6

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Vesicle-associated membrane protein 4 (VAMP4)

Variant Association Phenotype Notes Author
rs15655 Allelic: significant in both samples: 1. exploratory step: p1=.004 2. combined sample: p=.019, OR 1.63 95%CI 1.21-2.21 Suicide attempts Ethnicity: Caucasian, Ukranian, Russian, or East European

Wasserman, 2005

Sample 1 (exploratory analyses): N:77 triplets; mean age: 22.7±6.5; F: 46.8%
Sample 2 (validation analyses): N=190 triplets; mean age: 24.7±7.6; F: 41.1 %
Notes: TDT test; no asociation with major depression
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Prenylated Rab acceptor 1 (RABAC1)

Variant Association Phenotype Notes Author
rs1428922

Allelic: significant in the exploratory (p1=.006) but not in validation analyses

Suicide attempts Ethnicity: Caucasian, Ukranian, Russian, or East European

Wasserman, 2005

Sample 1 (exploratory analyses): N:77 triplets; mean age: 22.7±6.5; F: 46.8%
Sample 2 (validation analyses): N=190 triplets; mean age: 24.7±7.6; F: 41.1 %
Notes: TDT test; no asociation with major depression

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Dopamine-and-cAMP-regulated phosphoprotein (DARPP32)

Variant Association Phenotype Notes Author

rs907094

rs9532

Allelic: ns

Allelic: p=.014 (SN vs UC)

Suicide Ethnicity: Caucasian

 

Feldcamp, 2008

Postmortem cases: with schizophrenia dying by suicide (SN): n:6 (F:3, mean age:36.5±7.7); with schizophrenia not dying by suicide (SNS): n:29 (F:6,mean age:43.8±8.3); bipolar disorder dying by suicide: n:16 (F:8; mean age:45.1±9.8) or not dying by suicide: n: 18 (F:9, mean age:46.2±11.0)
Postmortem (unaffected) controls (UC): n:34 (F:9; mean age:43.8±7.6)
Notes: schizophrenia patients dying by suicide had significantly different gene expression levels from those dying from other causes.

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Cholecystokinin (CCK)

Variant Association Phenotype Notes Author
IG196A Allelic:+, A, OR=3.46 95% CIs 1.13-10.63, in males
Genotypic: ns
Suicide Ethnicity: Japanese

 

Shindo, 2005

Cases: suicides: n:154 (F:44); age range:17-92
Volunteer controls: n:328 (F:155)
C45T Allelic: ns
Genotypic: ns
Notes: Bonferoni adjusted analyses; confounders: gender, age

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Wolfram Syndrome 1 (WFS1)

Variant Association Phenotype Notes Author
H611R Genotypyc:+ HR, p=0.023 χ2=7.505 df=2 Mood disorders Ethnicity: Caucasian Zalsman, 2009
Mood disorders: 201 (69,7%F) mean age: 41.0±14.4, Suicide attempters: 33,8%
Controls: 113 healthy volunteers
H611R Allelic: ns
Genotypic: +, 611R/ 611R, p=.001
Suicide Ethnicity: French Canadians

 

Sequeira, 2003

R456H Allelic: ns
Genotypic: ns
Suicide completers: n:111, mean age: 32.20±9.38
I333V Allelic: ns
Genotypic:ns
Nonpsychiatric/nonsuicidal controls: n:129, mean age: 34±10.56
Notes: H611R/ H611R suicides had higher impulsivity and novelty seeking after adjusting for confounders; adjusted for multiple testing
33 variants

Allelic: ns
Genotypic:ns

Suicide

Ethnicity: Caucasian, South Australian

Crawford, 2002

Cases: Suicides: n:100 age:<65
Nonpsychiatric controls: n:60; Nondepresed and nonsuicidal controls: n:100, mean age: 42.5
Notes: 6 missense changes exclusive to completers: A326V, E394V, L499F, A671V, V871M, A559T; 7 newly identified amino-acid-changing variants were in exon 8 & 4 of those found only in suicides
H611R Allelic: ns
Genotypic:ns
Suicide attempts Ethnicity: Caucasian, East Anglian/ UK Furlong, 1999
Cases: Unipolar depressive cases: F:106; M:57; suicidal: 87; Bipolar I cases: F:92; M:66; suicidal: 70
Controls:  n:316
Notes: 559Thr variant may be a risk allele for affective disorder

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Apolipoprotein Epsilon 4 (APOE4)

Variant Association Phenotype Notes Author
E4 Allelic: +, E4, p=.012 OR=4.32 95% CIs 1.51-12.36 Suicide attempts Ethnicity: Chinese

 

Hwang, 2006

Cases: Geriatric depressed patients: N:111 (F:47, 23 suicide attempters); mean age: 75.0±5.2
Sex-matched, non-depressed controls without dementia: n:144; mean age:74.0±8.5
Notes: No association with depression
C3937T C4075CT Allelic: ns
Genotypic:ns
Suicide Ethnicity: Caucasian, French-Canadian Lalovic, 2004
Cases: 145 male suicides (mean age: 36.1±10.7)
160 controls with no psychiatric diagnoses, matched geographically (mean age:33.5±9.9)
Notes: no genotypic association with impulsivity or aggression

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

HMG CoA Reductase (HMGCR)

Variant Association Phenotype Notes Author
(TTA)n Allelic: ns
Genotypic: ns
Suicide Ethnicity: Caucasian, French-Canadian Lalovic, 2004
Cases: 145 male suicides ( mean age: 36.1±10.7)
160 controls with no psychiatric diagnoses, matched geographically (mean age:33.5±9.9)
Notes: no genotypic association with impulsivity or aggression

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

7-Dehydrocholesterol Reductase (DHCR7)

Variant Association Phenotype Notes Author
IVS8-1GC Allelic: ns
Genotypic: ns
Suicide Ethnicity: Caucasian, French-Canadian Lalovic, 2004
Cases: 145 male suicides mean age: 36.1±10.7)
160 controls with no psychiatric diagnoses, matched geographically (mean age:33.5±9.9)
Notes: no genotypic association with impulsivity or aggression

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Lipoprotein Lipase (LPL)

Variant Association Phenotype Notes Author
PvuIICT Allelic: ns
Genotypic:ns
Suicide Ethnicity: Caucasian, French-Canadian Lalovic, 2004
Cases: 145 male suicides ( mean age: 36.1±10.7)
160 controls with no psychiatric diagnoses, matched geographically (mean age:33.5±9.9)
Notes: no genotypic association with impulsivity or aggression

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

 

Low-density Lipoprotein Receptor (LDLR)

Variant Association Phenotype Notes Author
PvuIICT Allelic: ns
Genotypic:ns
Suicide Ethnicity: Caucasian, French-Canadian

Lalovic, 2004

Cases: 145 male suicides (mean age: 36.1±10.7)
160 controls with no psychiatric diagnoses, matched geographically (mean age:33.5±9.9)
Notes: no genotypic association with impulsivity or aggression

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

cAMP responsive element binding protein 1 (CREB1)

Variant Association Phenotype Notes Author
rs7569963

Allelic:-, G, p=.005, males

Treatment emergent suicidal ideas

Multicenter study in the USA

Perlis, 2007

 

 rs4675690 Allelic:+, T, OR: 1.9 95% CI 1.3 - 2.9, males Cases: nonpsychotic major depressive patients treated with citalopram hydrobromide for up to 12 weeks. Of 1447 (M:539, mean age: 42.5+ 13.4) participants, 124 had treatment emergent suicidal ideas and 124 attempted suicide

rs2709376

Allelic: ns
rs2253206 Allelic: ns
 rs7594560 Allelic: ns Controls: 1324 participants without treatment emergent suicidal ideas

 

 

 

 

Haplotypic: -, haplotype 1, p=.004, men

Haplotypic: +, haplotype 4, allele, p=.009 , men Notes: risk of emergence of suicidality associated with 2 SNPs that were previously linked to anger; no association with suicide attempts or emerging suicidality after 30 days

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Nitric oxide synthase 1 (neuronal) (NOS 1)

Variant Association Phenotype Notes Author
rs2682826 rs6490121 rs3782206 rs561712 rs3782219 rs3782221 rs41279104

Genotypic; s, rs2682826, p=0.0007

Allelic; s, rs2682826, minor T, s, p=0.0005

Suicide Ethnicity: Japanese Cui 2010
Cases: 284 suicide completers (F: 91, Female 46.9±19.5, Male 48.9±16.4)
Control: 287 healthy control (F: 102, Female 53.6 ± 14.3, Male 47.2 ± 18.7)
Notes: Of all the SNPs investigated, rs2682826 significant relationship in both genotypic and allelic evaluations to suicide completion. The other SNP p-values were indicated non-significant relationships.
NOS1 Ex1 VNTR1

Genotypic: +, SS, Suicide attempt, p=.02

Impulsive behaviors Population: 3200 subjects Reif, 2009
1954 controls
383 ADHD
151 familial ADHD
189 suicide attempters
182 criminal offenders

rs2682826

Allelic: ns

Genotypic: ns

 

Suicide &

suicide attempts

Ethnicity: Caucasian, mostly German

 

Rujescu, 2007

rs1353939

Allelic:ns

Genotypic: ns

Suicide attempters (M: 58, F:109; mean age: 39.89 ± 13.89)

Suicide completers (M:53, F:39; mean age: 51.8 ±18.5)
rs2293049

Allelic:ns

Genotypic: ns

312 Healthy subjects (M:138, F:174, mean age: 45.01 ± 14.92)

rs693534

Allelic:+,G, OR: 2.51 95% CI 1.43-4.40, associated with suicidal behaviors, especially suicide attempts

Genotypic: ns

Notes: no association with violent or impulsive suicide attempt or familiarity for suicide attempt; several haplotypes and a single marker (rs693534) associated with aggressive and anger traits

  Haplotype: multiple

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Nitric oxide synthase 3 (endothelial cell) (NOS 3)
 
Variant Association Phenotype Notes Author

rs2070744

Allelic:ns

Genotypic: ns

 

Suicide & suicide attempts

Ethnicity: Caucasian, mostly German

 

Rujescu, 2007

rs1799983

Allelic:ns

Genotypic: ns

1. Suicide attempters (M: 58, F:109; mean age: 39.89 ± 13.89)

Suicide completers (M:53, F:39; mean age: 51.8 ±18.5)
rs891512

Allelic:, -, A,p = 0.007, especially in suicide completers

Genotypic: ns

312 healthy subjects (M:138, F:174, mean age: 45.01 ± 14.92)

  Haplotypic: -, multiple, especially in suicide completers

Notes: no association with violent or impulsive suicide attempt or familiarity for suicide attempt; several haplotypes associated with aggressive and anger traits

T786C

Intron 4, 27bp repeat

Genotypic: ns
Allelic: ns

Haplotypic: ns
Suicide attempts

Ethnicity: Caucasian, Spanish

Saiz , 2007
Suicide attempters [n:186 (F:63.4%), mean age: 35.0± 11.9]
Healthy controls [n:420 (F:48.6%), mean age: 40.6± 11.3]
Notes: no association with impulsivity of attempt and sex

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

T-box 19 (TBX 19)

Variant Association Phenotype Notes Author



rs1000533

 

Allelic: +, C, P <.05

 

Suicide attempts with high angry/hostility scores Ethnicity: Ukraine, Odessa

Wasserman 2007

1. explorative phase (associations of
130 candidates SNPs to neuroticism in non-suicidal individuals): a. screening sample  (nonsuicidal parents: n=127 were used for screening and replication) and b. replication sample (nonsuicidal parents and volunteers: n=617)

2. transmission of significant markers from parents to suicidal offspring using TDT in 272 trios: a. sample F (272 trios-including 22 trios used and 127 parents used in the first step-including 192 suicide attempters);
b. a subgroup of 65 trios with high  angry/hostility (ANG)
Haplotypic:
+, GAC, suicide attempter offspring, p<.05 

Notes: 1. screening in nonsuicidal sample for broad NEO traits yielded 3 SNPS (: rs1000533 in the TBX19
gene, rs1864793 in GABRA5 gene and rs222843 in the GABARAP gene.
2. four significant SNP associationswith neuroticism facets in TBX19 and GABRA5 genes
3. replicated associations with angry hostility and  rs1000533 and anxiety and TBX19
4. Standard TDT analyses for the implicated rs1000533 C-allele showed no overtransmission

5. Standard (ANG group) and quantitative TDT (192 trios) showed a tendency for increased angry/hostility scores in C-allele carriers among the
suicide attempter offspring.

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Angiotensinogen (serpin peptidase inhibitor, clade A, member 8)(AGT)

Variant Association Phenotype Notes Author

M235T

Allelic: ns
Genotypic: ns

Suicide

Ethnicity: Kobe city, Japan descent

Hishimoto 2006

Cases: 166 suicides [M:115,  mean age: 47.9± 16.1; F:51, 49.1 ±20.1) ]
166 sex/age-matched healthy volunteer controls [M:115,mean age: 46.7 ±15.9; F:51, 47.6 ±18.3]
Notes: Bonferroni-corrected; part of a larger study of 4 four functional polymorphisms in RAS-related genes

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Angiotensin II receptor, type 1 (AGTR1)

Variant Association Phenotype Notes Author

A1166C

 

Allelic: ns
Genotypic: ns

Suicide

Ethnicity: Kobe city, Japan descent

Hishimoto 2006

Cases: 166 suicides [M:115,  mean age: 47.9± 16.1; F:51, 49.1 ±20.1) ]
166 sex/age-matched healthy volunteer controls [M:115,mean age: 46.7 ±15.9; F:51, 47.6 ±18.3]
Notes: Bonferroni-corrected; part of a larger study of 4 four functional polymorphisms in RAS-related genes

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

G protein b 3(GNB3)

Variant Association Phenotype Notes Author

C825T

Allelic: ns
Genotypic: ns

Suicide

Ethnicity: Kobe city, Japan descent

Hishimoto 2006

Cases: 166 suicides [M:115,  mean age: 47.9± 16.1; F:51, 49.1 ±20.1) ]
166 sex/age-matched healthy volunteer controls [M:115,mean age: 46.7 ±15.9; F:51, 47.6 ±18.3]
Notes: Bonferroni-corrected; part of a larger study of 4 four functional polymorphisms in RAS-related genes

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

X-box binding protein 1 (XBP1)

Variant Association Phenotype Notes Author

C116G

Allelic: ns
Genotypic: ns

Suicide

Ethnicity: Japanese descent

Sakurai, 2007

188 suicides [F:62, mean age: 47.7± 17.6]
184 healthy controls [F:61, mean age: 44.8± 16.6]
Notes: also examined ATF6 gene, finding no association

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Heat shock 70-kDa protein 5 (HSPA5)

Variant Association Phenotype Notes Author

rs17840761

rs3216733

rs12009

Allelic: ns
Genotypic: ns

Suicide

Ethnicity: Japanese descent

Sakurai, 2007

188 suicides [F:62, mean age: 47.7± 17.6]
184 healthy controls [F:61, mean age: 44.8± 16.6]
Notes: also examined ATF6 gene, finding no association

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Immune system

Variant Association Phenotype Notes Author

- 1082 IL10

+874 INF γ

- 308 TNF α

IL-10: Genotypic + A/A p=0.017

INF γ: Genotypic + A/A p=0.017

TNF α: Genotypic+ G/G p=0.027

 

Suicide completers Ethnicity: Iranian population

Omrani, 2009

Controls: 160 normal persons, 70.6 ± 10
Cases: 145 suicide completers, mean age 25.82 ± 12.57 F=71
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Slit homolog 2 (SLIT2)

Variant Association Phenotype Notes Author

rs587032,

rs6447952,

rs16869521,

rs13140329,

rs13434430;

rs12509367;

rs593943

Allelic: s; rs593943

re-test using an independent sample of 403 C trios, SNP rs593943 again ranked highest on conditional power, with an overtransmission of the major T allele, as in SR trios (P = 0.026, one-tailed).

Suicide attempt

Ethnicity: Caucasian, Ukranian

Sokolowski, 2010

Cases: 269 screening and replication nuclear family trios, one offspring/trio

Control: 403 confirmation nuclear family trios, one offspring/trio

Note:SNP rs593943 (P = 0.013), remained the analysis identified two additional SNPs with a significant transmission disequilibrium rs13140329, minor T allele overtransmitted; rs13434430, major T allele overtransmitted;

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

v-akt murine thymoma viral oncogene homolog 1(AKT1)

Variant Association Phenotype Notes Author

AKT1

rs2494731, rs3803304 rs3730358 rs10149779 rs2494746 rs1130214 rs249878

AKTIP

rs9302648 rs7189819

Genotypic;

AKT1:

CC rs2494731, s, p<0.05 violent suicide attempt

GG rs2494746, s, p<0.05 attempted violent attack

TT rs1130214, s, p<0.05 suicide attempts

Haplotypic

rs2498784 rs1130214
C*T

C*G

 

Suicide attempt

Ethnicity: Assumed Brazilian due to location of study

Magno, 2010

Cases: 273 bipolar (F: 69.4%, 41.4±12.9)

Notes: Only SNP variations on AKT1 were linked to the suicidality and violent attack phenotypes- no AKTIP SNPs were found to be significant.

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males