P450 System Genes: CYP2D6 and CYP2C19
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
CYP2D6: alleles 3,4,5,6 & deletion or multiplication CYP2D1: alleles 2,3,4 |
Genotypic: ns
|
Suicide attempts
|
Cases: schizophrenia spectrum disorder patients: n:362 (59% men; mean age 44±9;178 attempters) |
Kobylecki, 2008
|
Notes: no asociation with substance abuse disorder |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
rs4606 | Genotypic: +, CC, χ2=10.47, respectively, p<.05, Prevalence of suicidal ideation | Suicidal ideation | 607 participants: 35.1% men, 64.9% women; 22.6% ≤ 59 years of age, 77.4% ≥ 60 years of age; 90% white, 3.9% black, 3.9% Hispanic, 1.7% other, 0.5% missing self-report race/ethnicity data. |
Amstadter, 2009 |
Genotypic:+,CC, χ2 n=8.28, p<.01 OR=5.30, 95% CI: 1.93-22.96, p<.05 (association with suicidal ideation) | ||||
rs2746072 |
Allelic: +, G, OR 1.4 (1.06–1.86)
Genotypic: ns |
Suicide | Ethnicity: Japanese |
|
rs4606 | Allelic :+,G, 1.5 (1.13–1.98) Genotypic: +,GG, p=.011 |
|||
rs2746012 | Allelic: ns Genotypic: ns |
Suicide completers: 189 (F:62, 47.8±17.5) | ||
rs3767488 | Allelic: ns Genotypic: ns |
Age/sex-matched controls: n:210 (F:71,46.1±18.1) | ||
Haplotypic: multiple combinations that include rs4606 | Notes: also did immunoreactivity on a subsample, finding it to be increased in the amygdala & BA9 |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author | A118G (rs1799971) | Allelic: ns Genotypic: -,AG+GG vs AA, OR=.63, 95% CI .42-.93 |
Suicide
|
Ethnicity: Japanese |
Hishimoto, 2008 | Completed suicides: F:60,mean age: 46.9±19.6; M: 123, mean age: 49.0±16.7 |
Controls: F: 213, mean age: 45.3±17.1; M: 161, mean age: 39.6±15.9
|
rs1074287 rs12205732 rs2075572 |
Allelic: ns
|
Haplotypic (A118G,rs1074287, rs12205732): ns |
Notes: included sex and age as covariates; corrected for multiple tests |
---|
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
ATP-binding cassette, sub-family G (WHITE), member 1(ABCG1)
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
G2457A | Allelic: ns Genotypic: ns |
Suicide attempts | Ethnicity: Caucasian [age:18-65] |
Rujescu, 2000 |
1. Original sample: a. inpatients with suicide attempts & psychiatric disorders [F:44; M:26] b.inpatients with uni/bipolar depression [F:35; M:17] c. population controls [F:49; M:48] | ||||
2. Replication sample: a. depressed outpatients [F:79; M:25] b. healthy controls [F:27; M:65] | ||||
Notes: original association with affective disorders not replicated |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Limbic system-associated membrane protein (LSAMP)
Variant | Association | Phenotype | Notes | Author | 30 tag SNPs | Allelic: ns |
Suicide
|
Cases: 288 male suicide victims (mean age: 42.8±13.69, 46 ) |
Must, 2000 | 2. 327 healthy male volunteers qirh no psychiatric history or suicide attempts (mean age: 40.5±14.49 ) | Notes: four significant allelic associations disappeared after correcting for multiple tests |
---|
Spermine/spermidine N1-acetyltransferase gene (SSAT)
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
rs6151267 | Allelic; s, D, p=.01 Suicide with depression vs. Non-suicide with depression | Suicide Completers | Ethnicity: French Canadian |
Fiori, 2010 |
Cases: 326 suicide (F: 0; 40.8 ± 13.5 ) | ||||
Control: 445 non-suicide (F: 0; 40.4 ± 13.5) | ||||
Notes: No significant difference between suicide and control, significant difference in frequency between suicide with depression and non-suicide with depression. | SSAT342A |
Allelic: +,C, OR 2.7 95% CI 1.4-5.3
|
Suicide
|
Ethnicity: French Canadian |
Sequiera, 2006 | Cases: 181 male suicide completers |
Controls: 80 males matched by age and ethnic origin. |
Notes: of the 4 examined loci (SSAT460,SSAT495,SSAT624,SSAT342), only SSAT342 sufficiently polymorphic; A allele associated with higher gene expression in BA4 and BA11. |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
Ala-9Val | Allelic: ns Genotypic: ns |
Suicide attempts | Ethnicity: Korean |
|
Cases: mood disorder patients: n: 141 (M:102) | ||||
Unrelated nonpsychiatric controls: n: 106 (M: 51) | ||||
Notes: no association with mood disorders |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
A/D | Genotypic: +, DD, (p<.001) |
Suicide | Ethnicity: Caucasian |
|
Cases: Neurological cases (n:276 including 31 suicides) | ||||
Non-neurological controls: n:103 | ||||
Notes: 64.2% of the suicides with depressive, manic-depressive and alcoholic diseases carried the D variant |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
rs827421 rs1913474 rs1801132 rs722207 rs974276 rs910416 | Allelic: ns |
Suicide attempts | Etnicity: German | Giegling, 2009 |
Cases: 111 Suicide attempters; 38.7% males, mean age: 39.2+/-13.6 | ||||
Controls: 289 subjects; 42.6% males, mean age: 45.2+/-14.9 | ||||
XbaI PvuII |
Allelic: ns Genotypic: ns |
Suicide attempts | Ethnicity: Han Chinese, Taiwan |
|
Cases: 154 major depressive patients: F:89; mean age: 46.8±17.4, 46 suicide attempters | ||||
226 healthy controls: F:126; Ethnicity: n:109 were Ashkenazi Jewish; mean age: 46.6±16.7 | ||||
Notes: In females, found PvuII allelic & genotypic differences |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
−1727A/T, −50C/T | Genotypic: ns Allelic:ns Haplotypic: ns |
Suicide attempts | Ethnicity: Korean |
Yoon, 2010 |
Cases: 170 suicidal depressed (F: 92; 40.28 ± 6.83 ), 147 non-suicide depressed (F: 79 39.87 ± 8.14) |
||||
Control: 164 (F: 89; 40.33 ± 7.52) |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
I/D | Genotypic: +, II, male suicides vs male control OR = 1.68, CI = 1.15–2.5, p = 0.007 male suicides vs female suicides OR = 2.11, CI = 1.24–3.6, p = 0.005 male suicides vs pooled controls 1.79, CI = 1.24–2.56, p = 0.001
|
Completed suicide | Ethnicity: Caucasian | Fudalej, 2009 |
Cases: n=150 (F: 30%) median age: 43 | ||||
Age- and sex-matched controls: n=165 (F:28.4%) | ||||
effect of number of the copies of the ACE I allele on method of suicide in males: hanging versus not jumping from height versus not jumping from |
||||
I/D | Allelic: ns Genotypic: ns |
Suicide attempts | Ethnicity: Chinese |
|
Sample: major depressive patients: n:93 (F:51, 51 suicide attempters; mean age: 46.7±18.3) | ||||
Notes: no association with major depression nor with antidepressant effects | ||||
I/D | Genotype: ns |
Suicide | Ethnicity: Kobe city, Japan descent |
|
Cases: suicides: M:115, mean age: 47.9± 16.1 years; F:51, mean age: 49.1 ±20.1 | ||||
Sex/age-matched healthy volunteer controls: M:115, mean age: 46.7 ±15.9; F:51, mean age: 47.6 ±18.3 | ||||
Notes: Bonferroni-corrected; Part of a larger study of 4 four polymorphisms in RAS-related genes |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
T5424C (rs1532976) |
Allelic: ns Genotypic: ns |
Suicide | Ethnicity: Japanese |
|
Cases: 185 suicides: age mean: 47.7±17.9; F:61 | ||||
C38340A (rs3752826) |
Allelic: ns Genotypic: ns |
359 non-psychiatric controls: F:206; age mean: 42.3±16.3 | ||
T55012C (rs9393) |
Allelic: ns Genotypic: ns |
Notes: Bonferoni adjusted analyses | ||
Haplotypic: +, multiple, p=.0005 |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
rs303802 | Allelic: significant in both samples: 1. exploratory step: p1=.008 2. combined sample: p=.005, OR 1.71, 95%CI 1.27-2.34 | Suicide attempts | Ethnicity: Caucasian, Ukranian, Russian, or East European | |
Sample 1 (exploratory analyses): N:77 triplets; mean age: 22.7±6.5; F: 46.8% |
||||
Sample 2 (validation analyses): N=190 triplets; mean age: 24.7±7.6; F: 41.1 % | ||||
Notes: TDT test; no asociation with major depression |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
rs16851799 rs7607967 rs4371369 rs4453709 rs4597545 rs4387806 rs6754031 rs12620053 rs13017637 rs12994338 rs4447616 |
Genotypic: ns | Borderline Personality Disorder | Ethnicity: Caucasian | Tadić, 2008 |
Cases:161 well-defined Caucasian Borderline Personality Disorder (BDP)patients M=49,F=112mean age ± SD = 33.2 ± 9.4 | ||||
Controls: 156, M=46 ,F= 110, mean age ± SD = 33.6 ± 9.6 |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
rs15655 | Allelic: significant in both samples: 1. exploratory step: p1=.004 2. combined sample: p=.019, OR 1.63 95%CI 1.21-2.21 | Suicide attempts | Ethnicity: Caucasian, Ukranian, Russian, or East European | |
Sample 1 (exploratory analyses): N:77 triplets; mean age: 22.7±6.5; F: 46.8% | ||||
Sample 2 (validation analyses): N=190 triplets; mean age: 24.7±7.6; F: 41.1 % | ||||
Notes: TDT test; no asociation with major depression |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
rs1428922 | Allelic: significant in the exploratory (p1=.006) but not in validation analyses |
Suicide attempts | Ethnicity: Caucasian, Ukranian, Russian, or East European | |
Sample 1 (exploratory analyses): N:77 triplets; mean age: 22.7±6.5; F: 46.8% | ||||
Sample 2 (validation analyses): N=190 triplets; mean age: 24.7±7.6; F: 41.1 % | ||||
Notes: TDT test; no asociation with major depression |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Dopamine-and-cAMP-regulated phosphoprotein (DARPP32)
Variant | Association | Phenotype | Notes | Author | rs907094 rs9532 |
Allelic: ns Allelic: p=.014 (SN vs UC) |
Suicide | Ethnicity: Caucasian |
|
Postmortem cases: with schizophrenia dying by suicide (SN): n:6 (F:3, mean age:36.5±7.7); with schizophrenia not dying by suicide (SNS): n:29 (F:6,mean age:43.8±8.3); bipolar disorder dying by suicide: n:16 (F:8; mean age:45.1±9.8) or not dying by suicide: n: 18 (F:9, mean age:46.2±11.0) | Postmortem (unaffected) controls (UC): n:34 (F:9; mean age:43.8±7.6) | Notes: schizophrenia patients dying by suicide had significantly different gene expression levels from those dying from other causes. |
---|
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
IG196A | Allelic:+, A, OR=3.46 95% CIs 1.13-10.63, in males Genotypic: ns |
Suicide | Ethnicity: Japanese |
|
Cases: suicides: n:154 (F:44); age range:17-92 | ||||
Volunteer controls: n:328 (F:155) | ||||
C45T | Allelic: ns Genotypic: ns |
Notes: Bonferoni adjusted analyses; confounders: gender, age |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
H611R | Genotypyc:+ HR, p=0.023 χ2=7.505 df=2 | Mood disorders | Ethnicity: Caucasian | Zalsman, 2009 |
Mood disorders: 201 (69,7%F) mean age: 41.0±14.4, Suicide attempters: 33,8% | ||||
Controls: 113 healthy volunteers | ||||
H611R | Allelic: ns Genotypic: +, 611R/ 611R, p=.001 |
Suicide | Ethnicity: French Canadians |
|
R456H | Allelic: ns Genotypic: ns |
111 suicide completers: mean age: 32.20±9.38 | ||
I333V | Allelic: ns Genotypic:ns |
129 nonpsychiatric/nonsuicidal controls: mean age: 34±10.56 | ||
Notes: H611R/ H611R suicides had higher impulsivity and novelty seeking after adjusting for confounders; adjusted for multiple testing | ||||
33 variants | Allelic: ns |
Suicide | Ethnicity: Caucasian, South Australian |
|
Cases: Suicides: n:100; age:<65 | ||||
Nonpsychiatric controls: n:60; Nondepresed and nonsuicidal controls: n:100, mean age: 42.5 | ||||
Notes: 6 missense changes exclusive to completers: A326V, E394V, L499F, A671V, V871M, A559T; 7 newly identified amino-acid-changing variants were in exon 8 and 4 of those seen only in suicides | ||||
H611R | Allelic: ns Genotypic:ns |
Suicide attempts | Ethnicity: Caucasian, East Anglian/ UK | Furlong, 1999 |
Cases: nipolar depressive cases: F:106; M:57; suicidal: 87; Bipolar I cases: F:92; M:66; suicidal: 70 | ||||
Controls: n:316 | ||||
Notes: 559Thr variant may be a risk allele for affective disorder |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
E4 | Allelic: +, E4, p=.012 OR=4.32 95% CIs 1.51-12.36 | Suicide attempts | Ethnicity: Chinese |
|
Cases: geriatric depressed patients: N:111 (F:47, 23 suicide attempters); mean age: 75.0±5.2 | ||||
Sex-matched, non-depressed controls without dementia: n:144; mean age:74.0±8.5 | ||||
Notes: no association with depression | ||||
C3937T C4075CT | Allelic: ns Genotypic:ns |
Suicide | Ethnicity: Caucasian, French-Canadian | Lalovic, 2004 |
Cases: 145 male suicides ( mean age: 36.1±10.7) | ||||
160 controls with no psychiatric diagnoses, matched geographically (mean age:33.5±9.9) | ||||
Notes: no genotypic association with impulsivity or aggression |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
(TTA)n | Allelic: ns Genotypic: ns |
Suicide | Ethnicity: Caucasian, French-Canadian | Lalovic, 2004 |
Cases: 145 male suicides (mean age: 36.1±10.7) | ||||
160 controls with no psychiatric diagnoses, matched geographically (mean age:33.5±9.9) | ||||
Notes: no genotypic association with impulsivity or aggression |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
IVS8-1GC | Allelic: ns Genotypic: ns |
Suicide | Ethnicity: Caucasian, French-Canadian | Lalovic, 2004 |
Cases: 145 male suicides (mean age: 36.1±10.7) | ||||
160 controls with no psychiatric diagnoses, matched geographically (mean age:33.5±9.9) | ||||
Notes: no genotypic association with impulsivity or aggression |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
PvuIICT | Allelic: ns Genotypic:ns |
Suicide | Ethnicity: Caucasian, French-Canadian | Lalovic, 2004 |
Cases: 145 male suicides (mean age: 36.1±10.7) | ||||
160 controls with no psychiatric diagnoses, matched geographically (mean age:33.5±9.9) | ||||
Notes: no genotypic association with impulsivity or aggression |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
PvuIICT | Allelic: ns Genotypic:ns |
Suicide | Ethnicity: Caucasian, French-Canadian | Lalovic, 2004 |
Cases: 145 male suicides ( mean age: 36.1±10.7) | ||||
160 controls with no psychiatric diagnoses, matched geographically (mean age:33.5±9.9) | ||||
Notes: no genotypic association with impulsivity or aggression |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
rs7569963 | Allelic:-, G, p=.005, males |
Treatment emergent suicidal ideas | Multicenter study in the USA
|
Perlis, 2007
|
rs4675690 | Allelic:+, T, OR: 1.9 95% CI 1.3-2.9, males | |||
rs2709376 |
Allelic: ns | |||
rs2253206 | Allelic: ns | Cases: nonpsychotic major depressive patients treated with citalopram hydrobromide for up to 12 weeks. Of 1447 (M:539, mean age: 42.5+ 13.4) participants, 124 had treatment emergent suicidal ideas and 124 attempted suicide | ||
rs7594560 | Allelic: ns | Controls: 1324 participants without treatment emergent suicidal ideas | ||
|
Haplotypic:-, haplotype 1, p=.004, men |
|||
Haplotypic:+, haplotype 4, allele, p=.009 , men | Notes: risk of emergence of suicidality associated with 2 SNPs that were previously linked to anger; no association with suicide attempts or emerging suicidality after 30 days |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
rs2682826 rs6490121 rs3782206 rs561712 rs3782219 rs3782221 rs41279104 | Genotypic; s, rs2682826, p=0.0007 Allelic; s, rs2682826, minor T, s, p=0.0005 |
Suicide | Ethnicity: Japanese | Cui 2010 |
Cases: 284 suicide completers (F: 91, Female 46.9±19.5, Male 48.9±16.4) | ||||
Control: 287 healthy control (F: 102, Female 53.6 ± 14.3, Male 47.2 ± 18.7) | ||||
Notes: Of all the SNPs investigated, rs2682826 significant relationship in both genotypic and allelic evaluations to suicide completion. The other SNP p-values were indicated non-significant relationships. | ||||
NOS1 Ex1 VNTR1 | Genotypic: +, SS, Suicide attempt, p=.02 |
Impulsive behaviors | Population: 3200 subjects | Reif, 2009 |
1954 controls | ||||
383 ADHD | ||||
151 familial ADHD | ||||
189 suicide attempters | ||||
182 criminal offenders | ||||
rs2682826 |
Allelic:ns Genotypic: ns |
Suicide & suicide attempts |
Ethnicity: Caucasian, mostly German |
|
rs1353939 | Allelic:ns Genotypic: ns | Suicide attempters (M: 58, F:109; mean age: 39.89 ± 13.89) |
||
Suicide completers (M:53, F:39; mean age: 51.8 ±18.5) | ||||
rs2293049 | Allelic:ns Genotypic: ns | 312 healthy subjects (M:138, F:174, mean age: 45.01 ± 14.92) |
||
rs693534 | Allelic:+,G,OR: 2.51 95% CI 1.43-4.40, Genotypic: ns |
Notes: no association with violent or impulsive suicide attempt or familiarity for suicide attempt; several haplotypes and a single marker (rs693534) associated with aggressive and anger traits |
||
Haplotype: multiple |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
rs2070744 |
Allelic:ns Genotypic: ns |
Suicide & suicide attempts |
Ethnicity: Caucasian, mostly German |
|
rs1799983 | Allelic:ns Genotypic: ns |
Suicide attempters: M: 58, F:109; mean age: 39.89 ± 13.89 |
||
Suicide completers: M:53, F:39; mean age: 51.8 ±18.5 | ||||
rs891512 | Allelic:, -, A, p = 0.007, especially in suicide completers Genotypic: ns |
312 Healthy subjects (M:138, F:174, mean age: 45.01 ± 14.92) |
||
Haplotypic: -, multiple, especially in suicide completers | Notes: no association with violent or impulsive suicide attempt or familiarity for suicide attempt; several haplotypes associated with aggressive and anger traits |
|||
T786C Intron 4, 27bp repeat |
Allelic: ns Genotypic: ns |
Suicide attempts | Ethnicity: Caucasian, Spanish |
Saiz , 2007 |
Suicide attempters [n:186(F:63.4%), mean age: 35.0± 11.9] | ||||
Healthy controls [n:420(F:48.6%), mean age: 40.6± 11.3] | ||||
Notes: no association with impulsivity of attempt and sex |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
|
Allelic: +, C, p <.05
|
Suicide attempts with high angry/ hostility scores |
Ethnicity: Ukraine, Odessa | 1. explorative phase (associations of |
2. transmission of significant markers from parents to suicidal offspring using TDT in 272 trios: a. sample F (272 trios-including 22 trios used and 127 parents used in the first step-including 192 suicide attempters); b. a subgroup of 65 trios with high angry/hostility (ANG) |
Haplotypic: +, GAC, suicide attempter offspring, p<.05 |
Notes: 1. screening in nonsuicidal sample for broad NEO traits yielded 3 SNPS (: rs1000533 in the TBX19 |
---|
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
M235T |
Allelic: ns |
Suicide | Ethnicity: Kobe city, Japan descent |
|
Cases: 166 suicides [M:115, mean age: 47.9± 16.1; F:51, 49.1 ±20.1] | ||||
166 sex/age-matched healthy volunteer controls [M:115,mean age: 46.7 ±15.9; F:51, 47.6 ±18.3] | ||||
Notes: Bonferroni-corrected; part of a larger study of 4 four polymorphisms in RAS-related genes |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
A1166C
|
Allelic: ns |
Suicide | Ethnicity: Kobe city, Japan descent |
|
Cases: 166 suicides [M:115, mean age: 47.9± 16.1; F:51, 49.1 ±20.1 ] | ||||
166 sex/age-matched healthy volunteer controls [M:115,mean age: 46.7 ±15.9; F:51, 47.6 ±18.3] | ||||
Notes: Bonferroni-corrected; part of a larger study of 4 four functional polymorphisms in RAS-related genes |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
C825T |
Allelic: ns |
Suicide | Ethnicity: Kobe city, Japan descent |
|
Cases: 166 suicides [M:115, mean age: 47.9± 16.1; F:51, 49.1 ±20.1) ] | ||||
166 sex/age-matched healthy volunteer controls [M:115,mean age: 46.7 ±15.9; F:51, 47.6 ±18.3] | ||||
Notes: Bonferroni-corrected; part of a larger study of 4 four functional polymorphisms in RAS-related genes |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
116CG |
Allelic: ns |
Suicide | Ethnicity: Japanese descent |
|
188 suicides: F:62, mean age: 47.7± 17.6 | ||||
184 healthy controls:F:61, mean age: 44.8± 16.6 | ||||
Notes: also examined ATF6 gene, finding no association |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
rs17840761 rs3216733 rs12009 |
Allelic: ns |
Suicide | Ethnicity: Japanese descent |
|
188 suicides: F:62, mean age: 47.7± 17.6 | ||||
184 healthy controls: F:61, mean age: 44.8± 16.6 | ||||
Notes: also examined ATF6 gene, finding no association |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Immune system
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
- 1082 IL10 +874 INF γ - 308 TNF α |
IL-10: Genotypic + A/A p=0.017 INF γ: Genotypic + A/A p=0.017 TNF α: Genotypic+ G/G p=0.027
|
Suicide completers | Ethnicity: Iranian population | |
Controls: 160 normal persons, 70.6 ± 10 | ||||
Cases: 145 suicide completers, mean age 25.82 ± 12.57 F=71 |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
Slit homolog 2 (SLIT2)
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
rs587032, rs6447952, rs16869521, rs13140329, rs13434430; rs12509367; rs593943 |
Allelic: s; rs593943 re-test using an independent sample of 403 C trios, SNP rs593943 again ranked highest on conditional power, with an overtransmission of the major T allele, as in SR trios (P = 0.026, one-tailed). |
Suicide attempt | Ethnicity: Caucasian, Ukranian |
|
Cases: 269 screening and replication nuclear family trios, one offspring/trio |
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Control: 403 confirmation nuclear family trios, one offspring/trio |
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Note:SNP rs593943 (P = 0.013), remained the analysis identified two additional SNPs with a significant transmission disequilibrium rs13140329, minor T allele overtransmitted; rs13434430, major T allele overtransmitted; | ||||
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
v-akt murine thymoma viral oncogene homolog 1 AKT1
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
AKT1 rs2494731, rs3803304 rs3730358 rs10149779 rs2494746 rs1130214 rs249878 AKTIP rs9302648 rs7189819 |
Genotypic; AKT1: CC rs2494731, s, p<0.05 violent suicide attempt GG rs2494746, s, p<0.05 attempted violent attack TT rs1130214, s, p<0.05 suicide attempts Haplotypic rs2498784 rs1130214
|
Suicide attempt | Ethnicity: Assumed Brazilian due to location of study |
|
Cases: 273 bipolar (F: 69.4%, 41.4±12.9) |
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Notes: Only SNP variations on AKT1 were linked to the suicidality and violent attack phenotypes- no AKTIP SNPs were found to be significant. |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males