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| Variant | Association | Phenotype | Notes | Author |
|---|---|---|---|---|
SNP2AG |
Allelic: ns Genotypic: ns |
Suicide attempts | Ethnicity: Caucasian, Stockholm County |
Carmine, 2003 |
| Cases: schizophrenic patients [n:74, M:61%, ages: 22-90] | ||||
Healthy controls: n: 135, M:67%, ages: 25-86 |
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| (CTG)n | Allelic: ns Genotypic: ns |
Notes: no association with endophenotypes, DR2 density, or CSF monoamine metabolites; corrected for multiple testing; SNP2 associated with irritability and (CTG)n with extraversion |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
| Variant | Association | Phenotype | Notes | Author |
|---|---|---|---|---|
S205L |
Genotypic: ns | Suicide attempts | Ethnicity: African American (N:29) and European Americans (N:174) |
McGregor 2007 |
| Cases: 203 childhood-onset mood disorder (COMD) cases, including 102 attempters (F:77; mean age: 25.26± 3.88) and 101 nonattempters (F:59; mean age: 25.31 ±4.24) | ||||
Nonpsychiatric sex/ethnicity matched controls: N: 192 |
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Notes: no association with COMD risk |
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| S205L | Allelic: ns | Suicide attempts | Ethnicity: Japanese | Kunugi, 2004 |
| Cases: patients with major depression [F:105 M:59; mean age: 49.5±12.7], including 46 suicide attempters | ||||
| Matched nonpsychiatric controls [F:105 , M:59; mean age:47.4±9.5] | ||||
| Notes: L205 significantly less frequent in depressed patients, especially those with a history of suicide attempts |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males
| Variant | Association | Phenotype | Notes | Author |
|---|---|---|---|---|
| rs6265 | Genotypic:ns | Suicide attempts | Etnicity: Slovenian and Caucasian | Zarrilli, 2009 |
| Control: n=250 | ||||
| Cases: n=262 | ||||
| (mean age: 49.3 ± 17.6 vs. 50.3 ±18.5; t=.544;P=.587) (M/F: 167/83 vs. 188/74; χ²=.224; P=.250) | ||||
rs6265 rs11030102 rs7103873 rs10767664 rs1491850 rs1491851
|
Genotypic:ns Genotypic:ns Genotypic:ns Genotypic:ns Genotypic:ns Genotypic:C+;p=0.002 |
Suicide attempts; 5HTT availability |
Etnicity: Causasian | Henningsson, 2009 |
| Control:n=9 | ||||
| Cases:n=9 | ||||
| Notes: technic; Spect | ||||
| Val66Met (rs6265) | Genotypic:+, Val/Val , relapse, OR 2.62,p=.019 | post-treatment relapse in alcohol dependence | Ethnicity: Causasian | Wojnar, 2009 |
| Cases: 154 patients with alcohol dependence (mean age:43,7 ± 9,6, F: 24%). 66 (43%) reported a suicid attempt. | ||||
Val66Met (rs6265) |
Genotypic:+,GA/AA, OR 2.64 (1.23-5.70) | Suicide attempts |
Cases: 97 depressed suicide attempters (mean age:38.7 ±12.3, F: 75.3%) and 73 nonattempters (mean age:41.2 ±11.9, F: 61.6%) |
Sarchiapone, 2008 |
| Notes: no interaction between Val66Met genotype and emotional abuse. | ||||
G196A A633T LCPR |
Allelic:+,G,p=.045 Genotypic:+,GG,p=.011 |
Suicide attempts | Ethnicity: Caucasian | Vincze, 2008 |
Allelic: ns Genotypic: ns |
Cases: Bipolar suicide attempters (n:176,mean age:42.9 ±11.2, F:104) or nonattempters (n:254,mean age:43.2 ±14.2, F:121) | |||
| 370 controls (mean age:44.2 ±11.0, F:125) | ||||
Allelic: ns Genotypic: ns |
Notes: 5HTTLPR showed neither main nor interaction effect with G196A. | |||
Val66Met |
Genotypic:+,Val/Val, sexually abused, p=.003 | Violent suicide attempts |
Cases: 813 suicide attempters (mean age:39.8 ±12.9, F: 585), including 198 violent attempters (F:112, mean age: 40.7±11.7) and 615 nonviolent attempters (F:473, mean age: 39.45±13.2) |
Perroud, 2007 |
| Notes: no interaction between Val66Met genotype and severity of sexual abuse, emotional abuse, emotional neglect, physical neglect or abuse or age at onset and number of attempts. The severity of most types of childhood maltreatment associated with the number and onset of attempts | ||||
| Val66Me | Allelic:+,Met,p=.002 | Suicidal behavior | Ethnicity: Japanese | Iga, 2007 |
| Cases: n:154 (F:84; mean age: 45.1±15.2) major depressive patients | ||||
| Controls: N:154(F:84; mean age: 45.0±15.0) sex- and age-matched controls | ||||
| Notes: also examined link with mood disorder | ||||
Val66Met |
Genotypic: ns | Suicide attempts | Ethnicity: Chinese, Taiwan | Hwang, 2006 |
Cases: geriatric depressive patients: n:110 (F: 47); mean age: 75.0 ± 5.3 |
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| Community controls: n: 171 (F:78); mean age 76.0±5.5 years | ||||
| Notes: met allele overrepresented in depressed patients | ||||
| Val66Met | Genotypic: ns | Suicide attempts | Ethnicity: Chinese | Hong, 2003 |
| Cases: patients with major depression (n:84) or bipolar disorder (n:108) with no other Axis I diagnoses [F:117, M:75; mean age: 44.1±15.9], including 67 suicide attempters | ||||
| Nonpsychiatric controls: F:231, M:161; mean age:44.8±21.4] | ||||
Notes: no association with major depression |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=malesVal66Met=rs6265 (G196A)