Variant |
Association |
Phenotype |
Notes |
Author |
rs6265 |
Genotypic:ns |
Suicide attempts |
Etnicity: Slovenian and Caucasian |
Zarrilli, 2009 |
Control: n=250 |
Cases: n=262 |
(mean age: 49.3 ± 17.6 vs. 50.3 ±18.5; t=.544;P=.587) (M/F: 167/83 vs. 188/74; χ²=.224; P=.250) |
rs6265
rs11030102
rs7103873
rs10767664
rs1491850
rs1491851
|
Genotypic:ns
Genotypic:ns
Genotypic:ns
Genotypic:ns
Genotypic:ns
Genotypic:C+;p=0.002 |
Suicide attempts;
5HTT availability |
Etnicity: Causasian |
Henningsson, 2009 |
Control:n=9 |
Cases:n=9 |
Notes: technic; Spect |
Val66Met (rs6265) |
Genotypic:+, Val/Val , relapse, OR 2.62,p=.019 |
post-treatment relapse in alcohol dependence |
Ethnicity: Causasian |
Wojnar, 2009 |
Cases: 154 patients with alcohol dependence (mean age:43,7 ± 9,6, F: 24%). 66 (43%) reported a suicid attempt. |
Val66Met (rs6265) |
Genotypic:+,GA/AA, OR 2.64 (1.23-5.70) |
Suicide attempts |
Cases: 97 depressed suicide attempters (mean age:38.7 ±12.3, F: 75.3%) and 73 nonattempters (mean age:41.2 ±11.9, F: 61.6%) |
Sarchiapone, 2008 |
Notes: no interaction between Val66Met genotype and emotional abuse. |
G196A
A633T
LCPR |
Allelic:+,G,p=.045
Genotypic:+,GG,p=.011 |
Suicide attempts |
Ethnicity: Caucasian |
Vincze, 2008 |
Allelic: ns
Genotypic: ns |
Cases: Bipolar suicide attempters (n:176,mean age:42.9 ±11.2, F:104) or nonattempters (n:254,mean age:43.2 ±14.2, F:121) |
370 controls (mean age:44.2 ±11.0, F:125) |
Allelic: ns
Genotypic: ns |
Notes: 5HTTLPR showed neither main nor interaction effect with G196A. |
Val66Met |
Genotypic:+,Val/Val, sexually abused, p=.003 |
violent suicide attempts |
Ethnicity: Caucasian |
Perroud, 2007 |
Cases: 813 suicide attempters (mean age:39.8 ±12.9, F: 585), including 198 violent attempters (F:112, mean age: 40.7±11.7) and 615 nonviolent attempters (F:473, mean age: 39.45±13.2) |
Notes: no interaction between Val66Met genotype and severity of sexual abuse, emotional abuse, emotional
neglect, physical neglect or abuse or age at onset and number of attempts.
The severity of most types of childhood maltreatment associated with the number and onset of attempts |
|
|
|
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Val66Met |
Genotypic: ns |
Suicide attempts |
Ethnicity: Chinese, Taiwan |
Hwang, 2006 |
Cases: geriatric depressive patients [n:110, F: 47; mean age: 75.0±5.3]
|
Community controls: [n: 171,F:78; mean age: 76.0±5.5 years] |
Notes: met allele overrepresented in depressed patients |
Val66Met |
Genotypic: ns |
Suicide attempts |
Ethnicity: Chinese |
Hong, 2003 |
Cases: patients with major depression (n:84) or bipolar disorder (n:108) with no other Axis I diagnoses [F:117, M:75; mean age: 44.1±15.9], including 67 suicide attempters |
Nonpsychiatric controls: F:231, M:161; mean age: 44.8±21.4 |
Notes: no association with major depression nor antidepressant effects |