SBGAS1

Notch Homolog 4 (NOTCH4)


Variant	Association	Phenotype	Notes	Author
SNP2AG	Allelic: ns Genotypic: ns	Suicide attempts	Ethnicity: Caucasian, Swedish	Carmine, 2003
			Cases: schizophrenic patients [n:74, M:61%, ages: 22-90]
			Healthy controls: n: 135, M:67% , ages:25-86
(CTG)n	Allelic: ns Genotypic: ns		Notes: no association with endophenotypes, DR2 density, or CSF monoamine metabolites; corrected for multiple testing; SNP2 A variant associated with irritability and (CTG)n with extraversion

Notes: += positive,significant; -=negative,significant; ns= nonsignificant; F=females; M=males

Variant	Association	Phenotype	Notes	Author
S205L rs1035050 rs2671641	Genotypic: ns	Suicide attempts	Ethnicity: African American (N:29) and European Americans (N:174)	McGregor 2007
Cases: 203 childhood-onset mood disorder (COMD) cases, including 102 attempters (F:77; mean age: 25.26± 3.88) and 101 nonattempters (F:59; mean age: 25.31 ±4.24)
192 nonpsychiatric sex/ethnicity matched controls
Notes: no association with COMD risk
S205L	Allelic: ns	Suicide attempts	Ethnicity: Japanese	Kunugi, 2004
Cases: patients with major depression [F:105, M:59; mean age: 49.5±12.7], including 46 suicide attempters
Matched nonpsychiatric controls [F:105 , M:59; mean age: 47.4±9.5]
Notes: L205 significantly less frequent in depressed patients, especially those with a history of suicide attempts

Variant

Association

Phenotype

Notes

Author

S205L
rs1035050
rs2671641

Genotypic: ns

Suicide attempts

Ethnicity: African American (N:29) and European Americans (N:174)

McGregor 2007

Cases: 203 childhood-onset mood disorder (COMD) cases, including 102 attempters (F:77; mean age: 25.26± 3.88) and 101 nonattempters (F:59; mean age: 25.31 ±4.24)

192 nonpsychiatric sex/ethnicity matched controls

Notes: no association with COMD risk

S205L

Allelic: ns

Suicide attempts

Ethnicity: Japanese

Kunugi, 2004

Cases: patients with major depression [F:105, M:59; mean age: 49.5±12.7], including 46 suicide attempters

Matched nonpsychiatric controls [F:105 , M:59; mean age: 47.4±9.5]

Notes: L205 significantly less frequent in depressed patients, especially those with a history of suicide attempts

Variant	Association	Phenotype	Notes	Author
rs6265	Genotypic:ns	Suicide attempts	Etnicity: Slovenian and Caucasian	Zarrilli, 2009
Control: n=250
Cases: n=262
(mean age: 49.3 ± 17.6 vs. 50.3 ±18.5; t=.544;P=.587) (M/F: 167/83 vs. 188/74; χ²=.224; P=.250)
rs6265 rs11030102 rs7103873 rs10767664 rs1491850 rs1491851	Genotypic:ns Genotypic:ns Genotypic:ns Genotypic:ns Genotypic:ns Genotypic:C+;p=0.002	Suicide attempts; 5HTT availability	Etnicity: Causasian	Henningsson, 2009
Control:n=9
Cases:n=9
Notes: technic; Spect
Val66Met (rs6265)	Genotypic:+, Val/Val , relapse, OR 2.62,p=.019	post-treatment relapse in alcohol dependence	Ethnicity: Causasian	Wojnar, 2009
Cases: 154 patients with alcohol dependence (mean age:43,7 ± 9,6, F: 24%). 66 (43%) reported a suicid attempt.
Val66Met (rs6265)	Genotypic:+,GA/AA, OR 2.64 (1.23-5.70)	Suicide attempts	Cases: 97 depressed suicide attempters (mean age:38.7 ±12.3, F: 75.3%) and 73 nonattempters (mean age:41.2 ±11.9, F: 61.6%)	Sarchiapone, 2008
Notes: no interaction between Val66Met genotype and emotional abuse.
G196A A633T LCPR	Allelic:+,G,p=.045 Genotypic:+,GG,p=.011	Suicide attempts	Ethnicity: Caucasian	Vincze, 2008
Allelic: ns Genotypic: ns	Cases: Bipolar suicide attempters (n:176,mean age:42.9 ±11.2, F:104) or nonattempters (n:254,mean age:43.2 ±14.2, F:121)
370 controls (mean age:44.2 ±11.0, F:125)
Allelic: ns Genotypic: ns	Notes: 5HTTLPR showed neither main nor interaction effect with G196A.
Val66Met	Genotypic:+,Val/Val, sexually abused, p=.003	violent suicide attempts	Ethnicity: Caucasian	Perroud, 2007
Cases: 813 suicide attempters (mean age:39.8 ±12.9, F: 585), including 198 violent attempters (F:112, mean age: 40.7±11.7) and 615 nonviolent attempters (F:473, mean age: 39.45±13.2)
Notes: no interaction between Val66Met genotype and severity of sexual abuse, emotional abuse, emotional neglect, physical neglect or abuse or age at onset and number of attempts. The severity of most types of childhood maltreatment associated with the number and onset of attempts

Val66Met	Genotypic: ns	Suicide attempts	Ethnicity: Chinese, Taiwan	Hwang, 2006
Cases: geriatric depressive patients [n:110, F: 47; mean age: 75.0±5.3]
Community controls: [n: 171,F:78; mean age: 76.0±5.5 years]
Notes: met allele overrepresented in depressed patients
Val66Met	Genotypic: ns	Suicide attempts	Ethnicity: Chinese	Hong, 2003
Cases: patients with major depression (n:84) or bipolar disorder (n:108) with no other Axis I diagnoses [F:117, M:75; mean age: 44.1±15.9], including 67 suicide attempters
Nonpsychiatric controls: F:231, M:161; mean age: 44.8±21.4
Notes: no association with major depression nor antidepressant effects

Variant

Association

Phenotype

Notes

Author

rs6265

Genotypic:ns

Suicide attempts

Etnicity: Slovenian and Caucasian

Zarrilli, 2009

Control: n=250

Cases: n=262

(mean age: 49.3 ± 17.6 vs. 50.3 ±18.5; t=.544;P=.587) (M/F: 167/83 vs. 188/74; χ²=.224; P=.250)

rs6265

rs11030102

rs7103873

rs10767664

rs1491850

rs1491851

Genotypic:ns

Genotypic:C+;p=0.002

Suicide attempts;

5HTT availability

Etnicity: Causasian

Henningsson, 2009

Control:n=9

Cases:n=9

Notes: technic; Spect

Val66Met (rs6265)

Genotypic:+, Val/Val , relapse, OR 2.62,p=.019

post-treatment relapse in alcohol dependence

Ethnicity: Causasian

Wojnar, 2009

Cases: 154 patients with alcohol dependence (mean age:43,7 ± 9,6, F: 24%). 66 (43%) reported a suicid attempt.

Val66Met (rs6265)

Genotypic:+,GA/AA, OR 2.64 (1.23-5.70)

Suicide attempts

Cases: 97 depressed suicide attempters (mean age:38.7 ±12.3, F: 75.3%) and 73 nonattempters (mean age:41.2 ±11.9, F: 61.6%)

Sarchiapone, 2008

Notes: no interaction between Val66Met genotype and emotional abuse.

G196A

A633T

LCPR

Allelic:+,G,p=.045

Genotypic:+,GG,p=.011

Suicide attempts

Ethnicity: Caucasian

Vincze, 2008

Allelic: ns

Genotypic: ns

Cases: Bipolar suicide attempters (n:176,mean age:42.9 ±11.2, F:104) or nonattempters (n:254,mean age:43.2 ±14.2, F:121)

370 controls (mean age:44.2 ±11.0, F:125)

Allelic: ns

Genotypic: ns

Notes: 5HTTLPR showed neither main nor interaction effect with G196A.

Val66Met

Genotypic:+,Val/Val, sexually abused, p=.003

violent suicide attempts

Ethnicity: Caucasian

Perroud, 2007

Cases: 813 suicide attempters (mean age:39.8 ±12.9, F: 585), including 198 violent attempters (F:112, mean age: 40.7±11.7) and 615 nonviolent attempters (F:473, mean age: 39.45±13.2)

Notes: no interaction between Val66Met genotype and severity of sexual abuse, emotional abuse, emotional neglect, physical neglect or abuse or age at onset and number of attempts. The severity of most types of childhood maltreatment associated with the number and onset of attempts

Val66Met

Genotypic: ns

Suicide attempts

Ethnicity: Chinese, Taiwan

Hwang, 2006

Cases: geriatric depressive patients [n:110, F: 47; mean age: 75.0±5.3]

Community controls: [n: 171,F:78; mean age: 76.0±5.5 years]

Notes: met allele overrepresented in depressed patients

Val66Met

Genotypic: ns

Suicide attempts

Ethnicity: Chinese

Hong, 2003

Cases: patients with major depression (n:84) or bipolar disorder (n:108) with no other Axis I diagnoses [F:117, M:75; mean age: 44.1±15.9], including 67 suicide attempters

Nonpsychiatric controls: F:231, M:161; mean age: 44.8±21.4

Notes: no association with major depression nor antidepressant effects