Gene Candidates





Reviews and Metanalyses

Kuzelova H, Ptacek R, Macek M. The serotonin transporter gene (5-HTT) variant and psychiatric disorders: review of current literature. Neuro Endocrinol Lett. 2010;31(1):4-10.

Mendlewicz J. Disruption of the circadian timing systems: molecular mechanisms in mood disorders.CNS Drugs. 2009;23 Suppl 2:15-26.

Roy A, Sarchiopone M, Carli V. Gene-environment interaction and suicidal behavior. J Psychiatr Pract. 2009 Jul;15(4):282-8.

Mazin AL. Suicidal function of DNA methylation in age-related genome disintegration. Ageing Res Rev. 2009 Oct;8(4):314-27. Epub 2009 May 21

Savitz J, Lucki I, Drevets WC. 5-HT(1A) receptor function in major depressive disorder. Prog Neurobiol. 2009 May;88(1):17-31. Epub 2009 Feb 7.

Kronenberg S, Frisch A, Rotberg B, Carmel M, Apter A, Weizman A. Pharmacogenetics of selective serotonin reuptake inhibitors in pediatric depression and anxiety. Pharmacogenomics. 2008 Nov;9(11):1725-36.

Pharmacogenomics with antidepressants in the STAR*D study. Lin E, Chen PS. Pharmacogenomics. 2008 Jul;9(7):935-46.

Currier D, Mann JJ. Stress, genes and the biology of suicidal behavior. Psychiatr Clin North Am. 2008 Jun;31(2):247-69.

Brezo J, Klempan T, Turecki G. The genetics of suicide: a critical review of molecular stuies. Psychiar Clin North Am. 2008;31(2):179-203.

Kia-Keating BM, Glatt SJ, Tsuang MT. Meta-analyses suggest association between COMT, but not HTR1B, alleles, and suicidal behavior. Am J Med Genet B Neuropsychiatr Genet. 2007 May 24;

Li D. He L. Meta-analysis supports association between sertonin transporter (5-HTT) and suicidal behavior. Molecular Psychiatry (2007) 12, 47-54.

Li D. He L. Further clarification of the contribution of the trypthophan hydroxylase (TPH) gene to suicidal behavior using systmeatic allelic and genoytpic meta-analyses. Human Genetics (2006): 119:233-240.

Bondy B, Buettner A, Zill P.  Genetics of suicide Mol Psychiatry. 2006 Apr;11(4):336-51. Review.

Courtet P, Jollant F, Castelnau D, Buresi C, Malafosse A.  Suicidal behavior: relationship between phenotype and serotonergic genotype.Am J Med Genet C Semin Med Genet. 2005 Feb 15;133(1):25-33. Review.

Lin PY, Tsai G. Association between serotonin transporter gene promoter polymorphism and suicide: results of a meta-analysis. Biol Psychiatry. 2004 May 15;55(10):1023-30.

Bellivier F, Chaste P, Malafosse A.  Association between the TPH gene A218C polymorphism and suicidal behavior: a meta-analysis. Am J Med Genet B Neuropsychiatr Genet. 2004 Jan 1;124(1):87-91.

Anguelova M, Benkelfat C, Turecki G.  A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: II. Suicidal behavior. Mol Psychiatry. 2003 Jul;8(7):646-53. Review.

Arango V, Huang YY, Underwood MD, Mann JJ.  Genetics of the serotonergic system in suicidal behavior. J Psychiatr Res. 2003 Sep-Oct;37(5):375-86. Review.


Jollant F, Buresi C, Guillaume S, Jaussent I, Bellivier F, Leboyer M, Castelnau D, Malafosse A, Courtet P.The influence of four serotonin-related genes on decision-making in suicide attempters.Am J Med Genet B Neuropsychiatr Genet. 2007 Jul 5;144(5):615-24.

Expression studies

Fiori LM, Mechawar N, Turecki G. Identification and characterization of spermidine/spermine N1-acetyltransferase promoter variants in suicide completers. Biol Psychiatry. 2009 Sep 1;66(5):460-7. Epub 2009 May 15.

Klempan TA, Ernst C, Deleva V, Labonte B, Turecki G. Characterization of QKI gene expression, genetics, and epigenetics in suicide victims with major depressive disorder.Biol Psychiatry. 2009 Nov 1;66(9):824-31. Epub 2009 Jul 9.

Klempan TA, Sequiera A, Cannetti L, Lalovic A, Ernst C, Ffrench-Mullen J, Turecki G. Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression. Mol Psychiatry. 2007 Oct 16.

Sequeira A, Klempan t, Canetti L, Ffrench-Mullen J, Benkelfat C, Rouleau GA, Turecki G. Patterns of gene expression in the limbic system of suicides with and without major depression.Mol Psychiatry. 2007 Jul;12(7):640-55.

S Dracheva, N Patel, D A Woo, S M Marcus, L J Siever and V Haroutunian. Increased serotonin 2C receptor mRNA editing: a possible risk factor for suicide. Molecular Psychiatry advance online publication 11 September 2007; doi: 10.1038/

Sequeira A, Turecki G.Genome-wide gene expression studies in mood disorders. OMICS. 2006 Winter: 10(4):444-54.


McGowan PO, Sasaki A, Huant TC, Unterberger A, Suderman M, Ernst C, Meaney MJ, Turecki G, Szyf M. Promoter-wide hypermethylation of the ribosomal RNA gene promoter in the suicide brain. PLoS ONE. 2008 May 7;3(5):e2085.


Young KA, Bonkale WL, HOlcomb LA, Hicks PB, German DC. Major depression, 5HTTLPR genotype, suicide and antidepressant influences on thalamic volume. The British Journal of Psychiatry 2008;192:285-289.

Other Psychiatric Phenotypes

Mamdani F, Alda M, Grof P, Young T, Rouleau G, Turecki G. American Journal of Medical Genetics Part B 2008; 147:500-4.