Variant |
Association |
Phenotype |
Sample Information |
Author |
C861G
G371T |
Allelic: ns |
Suicidal behaviour severity |
Cases: 336 (F:62%) bipolar patients from 305 nuclear families (mean age: 35.36± 10.37), including 267 patients with histories of suicide ideas or attempts |
De Luca, 2007 |
Notes: suicidality assessed quantitatively and coded as follows: 0 = absence of suicide/death thoughts, 1 = thoughts of death, 2 = suicide ideation, 3 = suicide plan, 4 = suicide attempt; marginal association of TH and severe suicidal behaviour |
A161T |
Allelic:+,T,p=.05 Genotypic:-,TT, p=.08 |
Suicide |
Ethnicity: French Canadian |
Zouk, 2007 |
T261G
C129T
G861C
A1180G
|
Allelic: ns
Genotypic: ns |
Cases: 338 suicide completers (F:64, mean age: 38 ± 11.04) |
Controls: 358 (F:75, mean age: 36.08 ± 15.71) nonsuicidal/nonpsychiatric controls |
Notes: 161T allele homozygotes had higher aggression scores; |
|
Haplotypic: ns |
A161T |
Allelic: ns
Genotypic: ns |
Suicide attempts |
Ethnicity: Han Chinese |
Tsai, 2004 |
Cases: 160 psychiatric outpatients with major depressive disorder (M:71, 15 suicide attempters, mean age: 44.9±16.8) |
Controls: n: 160, F:99,mean age: 42.5±8.2 |
Notes: no association with depression or fluoxetine response |
A161T |
Allelic: ns
Genotypic: ns |
Suicide attempts
|
Ethnicity: Han Chinese, Taiwan |
Hong, 2004 |
Cases: schizophrenia patients: F:59, M:51; mean age: 37.2±13.3 |
Healthy controls: F:124, M:91; mean age: 35.3±8.0 |
Notes: no association with schizophrenic disorders or aggression |
G861C |
Allelic: ns
Genotypic: ns |
Suicide attempts |
Ethnicity: German |
Rujescu, 2003 |
Cases: suicide attempters with mood disorders: F:96, M:52; age mean: 39.5±13.3 |
Volunteer controls:F:179, M:148; age mean: 45.8±14.9 |
Notes: attempters stratified by method violence and psychiatric diagnoses |
G861C |
Allelic: ns
Genotypic: ns |
Suicide attempts |
Cases: psychiatric patients: F:215, M:179; mean age: 38.9±13.6, including 132 suicide attempters; Ethnicity: Caucasian/African-American/Hispanic/Asian/Other: 280/45/55/7/7 |
Huang, 2003 |
Healthy volunteers: F:45, M:51; mean age: 40.9±15.9; Ethnicity: Caucasian/African-American/Hispanic/Asian/Other: 70/8/12/5/1 |
Notes: substance abuse and major depression associated with G861C |
G861C |
Allelic:+,G, p<.01, white subsample
|
Suicide attempts |
Ethnicity: Caucasian/Hispanic/African-American/Other: 90/27/24/4 |
New, 2001 |
Cases: personality disordered patients [F:59, M:86, mean age: 38.1±9.8], including 145 suicide attempters |
Notes: no association with impulsive aggression; Bonferroni-adjusted |
G861C |
Genotypic: ns |
Suicide |
Ethnicity: Slovenian |
Videtic, 2006 |
Cases: 226 suicides (M:74.8%, mean age 49.6±17.3) |
A161T |
Genotypic: ns |
225 healthy controls |
G861C |
Allelic: ns
Genotypic: ns |
Suicide |
Suicide victims [F:67, M:178,mean age: 47±19] Nonpsychiatric controls [F:120, M:128, mean age: 40±15] Ethnicity: German |
Stefulj, 2004 |
Suicide victims [F:32, M:86,mean age: 52±19] Nonpsychiatric controls [F:92, M:100, mean age: 43±12] Ethnicity: Croatian |
G861C |
Allelic: ns
Genotypic: ns |
Suicide |
Ethnicity: Caucasian, mostly French Canadian |
Turecki, 2003 |
106 suicide victims |
120 volunteer controls |
Notes: no difference according to method or psychopathology; Bonferroni-adjusted analyses |
G861C |
Allelic: ns
Genotypic: ns |
Suicide |
Ethnicity: Japanese |
Nishiguchi, 2001 |
Suicide victims: F:50, M:113; mean age: 47.9±17.6 |
Volunteer controls: F:50, M:113,;mean age: 44.7±14.9 |
G861C |
Allelic: ns
Genotypic: ns |
Suicide |
Suicide victims (F:19, M:52, mean age: 42.09±19.4); Ethnicity: White/black/ other: 51/8/12 |
Huang, 1999 |
C129T |
Allelic: ns
Genotypic: ns |
Nonsuicidal controls (F:25, M:82, mean age: 41.6±15.6) Ethnicity: White/black/other: 55/35/17 |
|
Notes: no association with major depression, alcoholism or pathological aggression |
Variant |
Association |
Phenotype |
Sample Information |
Author |
rs3125 rs6314 rs1745837 rs659734 rs1928042 rs2770296 rs582385 rs731779 rs6305 rs2070037 rs6313 rs1805055 |
Genotypic: ns Haplotypic :+, rs582385 - rs731779 - rs6303; p=0.05
|
Suicidal ideation |
Etnicity: Irish |
Fanous, 2009 |
Cohort: 1,425 individuals from 270 families having more than one member with DSMIII-R schizophrenia or poor outcome schizoaffective disorders. |
755 subjects with psychotic illness diagnosed by OPCRIT |
T102C |
Genotypic: +,CC, p=.033 relative to healthy controls
|
Suicide attempts |
Ethnicity: Spanish Caucasian
|
Vaquero-Lorenzo, 2008 |
Cases: 441 attempters: M:161; mean age: 38.5± 1.4 ) |
339 psychiatric controls:M:162,mean age: 41.9± 1.5 ) |
410 healthy controls: mean age: 36.2± 1.1; M:237) |
C1354T (His452Tyr) |
Genotypic:ns |
Notes: no difference between attempters and psychiatric controls |
T102C |
Allelic: ns
Genotypic: ns |
Suicide attempts |
Cases: 129 subjects meeting the diagnostic criteria for schizophrenia, including 42 suicide attempters (F: 19; Caucasian: 28, African: 14) and 87 nonattempters (F: 31, Caucasian: 56, African: 31)
|
Correa, 2007 |
Healthy controls (n: 85) |
Notes: no association with suicide attempt characteristics |
rs6311 rs6313 rs643627 rs1923882 rs7322347 |
Allelic: ns
Genotypic: ns
Haplotypic: ns |
Suicide attempts |
Ethnicity: Han Chinese |
Zhang, 2007 |
Cases: 297 (F:126; mean age 46.10 ± 12.76 ) suicide attempters |
Controls: 329 (F:112; mean age 43.22 ± 12.77) psychiatric patients without attempted suicide |
His452Tyr
C102T
|
Allelic: ns |
Suicidal behaviour severity |
Cases: 336 (F:62%) bipolar patients from 305 nuclear families (mean age: 35.36± 10.37 SD), including 267 patients with suicide ideas/ attempts |
De Luca, 2007 |
Notes: suicidality assessed quantitatively and coded as follows: 0 = absence of suicide/death thoughts, 1 = thoughts of death, 2 = suicide ideation, 3 = suicide plan, 4 = suicide attempt; marginal association between TH and severe suicidal behaviour |
rs63627 |
Allelic: ns |
Suicide attempts |
Ethnicity: German |
Giegling, 2006 |
rs594242 |
Allelic: ns |
Suicide attempts |
Cases: 203 suicide attempters (F:135; 133 nonviolent; 120 impulsive): age mean: 40.0±13.0 |
rs6311 |
Allelic:+, C, p=.009 |
Nonviolent suicide attempts |
Controls: 363 healthy volunteers (F:201): age mean: 46±15 |
Allelic:+, C, p=.01 |
Impulsive suicide attempts |
|
Haplotypic: multiple |
nonviolent or impulsive suicide attempts |
Notes: rs6311's CC genotypes showed more anger and aggression-related traits |
C102T |
Allelic: ns
Genotypic: ns |
Suicide attempts |
Ethnicity: Caucasian, European |
Khait, 2005 |
Cases: attempters with mood disorders [n:56 (F:42), age mean: 37.42±12.75] and nonattempters with mood disorders [n: 100 (F:58), age mean: 40.92±15.5)] |
Controls: n: 63 healthy volunteers, age mean: 40±17 |
C102T |
Allelic: ns
|
Suicide attempts |
Ethnicity: Ashkenazi Jewish |
Zalsman, 2005 |
Cases: families of recent teen attempters [n: 30 (F:16), mean age: 15.7±1.4] including 50 biological parents |
Notes: no association with clinical traits |
G1438A |
Allelic: ns
Genotypic: ns |
Suicide attempts |
Ethnicity: West European |
Etain, 2004 |
Cases: bipolar patients [F:198, M:158, mean age: 43±13.7] |
His452Tyr |
Allelic: ns
Genotypic: ns |
Healthy controls [F:116, M:92, mean age: 43±8.0] |
|
Haplotypic: ns |
Notes: no difference in relation to bipolar diagnosis, violent suicide attempts or family history of suicide attempts: Bonferroni-adjusted |
T102C |
Allelic: ns
Genotypic: ns |
Suicide attempts |
Ethnicity: European |
Oswald, 2003 |
Cases: 142 patients with unipolar affective disorder (UPD), including 33 suicide attempters |
Matched controls: 142 |
Notes: no association with UPD |
G1438A |
Allelic: ns
Genotypic: -, AA, p=.008, bipolar I |
Suicide attempts |
Ethnicity: Caucasian |
Bonnier, 2002 |
Cases: patients with unipolar (n:127) or bipolar (n:65) disorder [F:63%, mean age: 45.3±14.4] |
Nonpsychiatric controls [F:54.2%, mean age: 73.6±8.3] |
T102C |
Allelic: ns
Genotypic: ns |
Suicide attempts |
Ethnicity: Brazilian |
Correa, 2002 |
Cases: patients with recurrent major depression (n:78) or schizophrenia (n:95) including 66 suicide attempters |
Healthy controls: F:27, M:25 |
Notes: no difference in severity of attempts |
T102C |
Allelic: ns
Genotypic: ns |
Suicide attempts |
Ethnicity: Chinese |
Tan, 2002 |
Cases: schizophrenia patients with (n:47) or without suicide attempts (n:239), and with suicidal ideation (n:62) |
Nonpsychiatric controls (n:94) |
Notes: no association with schizophrenia |
T102C |
Allelic: ns
Genotypic: ns |
Suicide attempts |
Ethnicity: Spanish |
Arias, 2001 |
Cases: patients with major depression (n:159, mean age: 54.86±16.21, F: 108, 21% attempted suicide) |
Healthy controls (N:164, F: 81, mean age: 41.4±10.35) |
Notes: Bonferroni-adjusted; C allele carriers overrepresented in patients with seasonal depressive disorder |
T102C |
Allelic:+,C, p=.04
Genotypic: +, CC/CT, OR: 5.5 95% CI 1.18-35.20 |
Suicide attempts |
Ethnicity: Spanish |
Arias, 2001 |
Cases: patients with major depression (n:159, mean age: 54.86±16.21, 108 suicidal ideators and 33 suicide attempters, F: 108) |
Healthy controls (N:162 (F:81), mean age: 41.4±10.35) |
Notes: no association with major; C carriers overrepresented among suicidal ideators without suicide attempt histories |
C1/C2 |
Allelic: ns
Genotypic: ns |
Suicide attempts |
Ethnicity: European Caucasian, mostly Swedish |
Geijer, 2000 |
Cases: suicide attempters:F: 108, M: 57, mean age: 41 ±17 |
99 nonpsychiatric controls ( F:95, mean age 38±6) |
Notes: no association when stratified by diagnosis or ethnicity |
G1438A |
Allelic: ns
Genotypic: ns |
Suicide attempts |
Ethnicity: Japanese |
Ohara, 1998 |
Cases: mood-disordered patients [F:44, M:51, mean age: 44.9±16.2, including 14 suicide attempters] |
Healthy controls [F:59, M:47, mean age: 36.4±15.2] |
Notes: no association with mood disorders |
T102C |
Allelic:+,C, p=.005
Genotypic: +,CC, OR: 3.1 95% CI 1.7-5.8 |
Suicidal ideas |
Ethnicity: Caucasian |
Du, 2000 |
Cases: major depression patients, including 78 suicidal ideators: F:72, M:48, mean age: 39.32±9.53 |
Healthy controls: F:70, M:61, mean age: 35.95±11.34 |
Notes: C allele associated with major depression |
T102C |
Allelic: ns
Genotypic: ns |
Suicide attempts
Suicidal ideas |
Ethnicity: Caucasian, South Germany |
Preuss, 2000 |
Cases: patients with alcohol-dependence: F:31, M: 119, mean age: 41.4±9.3, including 45 suicide attempters |
General population controls: F:61, M:56, mean age: 46.8±12 |
Notes: not associated with depression |
T102C |
Allelic: ns
Genotypic: ns |
Suicidal ideas
Suicide |
Ethnicity: Caucasian, South Germany |
Bondy, 2000 |
Cases: 1. suicides: F:40, M:91, mean age:45.6± 16.4. 2. patients with major depression with or without suicidal thoughts: F:56, M:28, mean age: 52.8±11.9 |
Healthy controls: F:65, M:60, mean age: 47.8±12.4 |
Notes: no differences in the method of or age of victim; no association with major depression or suicide defined as a syndrome |
C1420T |
Genotypic: ns |
Suicide |
Ethnicity: Slovenian |
Videtic, 2006 |
Cases: 226 suicides (F:57, mean age ± SD, 49.6±17.3) |
225 healthy controls |
G1438A |
Allelic: ns
Genotypic: ns |
Suicide |
Ethnicity: Japanese |
Ono, 2001 |
Cases: suicides (M:106, mean age: 49.1±17.1; F:45,mean age: 45.8±19.2) |
General population controls (M:108, mean age: 44.9±15.3; F:55,mean age: 48.4±18.8) |
T102C |
Allelic: ns
Genotypic: ns |
Suicide |
Ethnicity: Largely Caucasian, South Australia |
Crawford, 2000 |
Cases: 68 suicides |
Controls: 95 |
T102C |
Allelic: ns
Genotypic: ns |
Suicide |
Geographic origin: Budapest |
Faludi, 2000 |
Cases: depressed suicides: n:32 |
Controls who died of causes unrelated to the CNS: n:57 |
His452Tyr |
Allelic: ns
Genotypic: ns |
T102CHis452Tyr |
Allelic: ns
Genotypic: ns |
Suicide
|
Location: Budapest |
Du, 1999 |
Cases: 24 depressed suicide completers ( mean age: 50.7 ± 30.2) |
Controls who died from nonsuicide-related causes and with no evidence of psychiatric illness were matched for age, sex, and postmortem delay (n:31, mean age: 45.5 ± 2.8) |
Notes: HTR2A genotypes not associated with frontal cortex density |
T102C |
Allelic: ns
|
Suicide |
Ethnicity: French Canadian |
Turecki, 1999 |
Cases: 56 suicides, mean age: 36.09±10.75 |
126 comparison subjects dying from cardivascular diseases, mean age: 33.54±9.95 |
G1438A |
Allelic: ns |
Notes: HTR2A binding greater in the prefrontal cortex of suicides and influenced by its DNA variation |
|
Haplotypic: ns |
T102C |
Allelic: ns
Genotypic: ns |
Suicidality |
Ethnicity: mixed |
Ertugrul, 2004 |
Cases: schizophrenia patients [F:20, M:51, mean age:32.8± 8.7] or schizoaffective disorder (n:6), currently suicidal patients [F:13, M:33, mean age:34.1± 8.9] |
Notes: suicidality defined on a continuum |