Tryptophan Hydroxylase 2 (TPH2) >
Variant Association Phenotype Sample Information Author


Allelic: .003

Suicides or major depression Ethnicity: Caucasian

Haghighi 2008


Cases: 82 patients with major depression or suicide (n:4)
g.22897A>G Allelic: .05 80 controls without major depression or suicide


g.22897A>G, rs1386494):

+, CGG, p=.01

Notes: the two variants associated with major depression and not with suicide alone


Allelic: ns
Genotypic: ns
Suicide attempts

Ethnicity: Caucasian [N=529 (94%)], Asian [N=26 (4.6%)], or multiple ethnic identities [N=8 (1.4%)]

Mann 2007
Cases: bipolar [n:109, M:61%, ages: 22-90] and major depressive patients [n:324], including 187 suicide attempters
Healthy controls: bipolar [n:130, M:61%, ages: 22-90]
Genotypic:+,CG, p<.001, in major depressive patients with childhood abuse Suicidal ideas Notes: CG genotype interaction with childhood abuse also related to increased depression and lifetime impulsivity scores; no association with depressive disorders or CSF levels of 5-HIAA, HVA, or MHPG





Allelic: ns Suicidal behaviour severity Cases: 336 (F:62%) bipolar patients from 305 nuclear families (mean age: 35.36± 10.37 SD), including 267 patients with suicide ideas or attempts De Luca, 2007
Notes: suicidality assessed quantitatively and coded as follows: 0 = absence of suicide/death thoughts, 1 = thoughts of death, 2 = suicide ideation, 3 = suicide plan, 4 = suicide attempt; marginal association between TH and severe suicidal behaviour
rs1386494 Allelic: ns Suicide attempts Cases: 2018 bipolar patients and families (F:64%, including 548 suicide attempters): Sample 1: N:1405; Sample 2: N: 613; Lopez, 2007
rs1007023 Allelic: ns
rs9325202 Allelic: ns Notes: analyses done in each sample separately and together. Observed the same haplotypic association with bipolar disorder suggesting that this haplotype is not an independent risk factor for suicide attempts.
Haplotypic: +, GTA, OR 1.2 95%CI 1.0-1.5
20 intronic SNPs

Allelic: ns

Haplotypic: ns

Suicide attempts

Ethnicity: German

ZIll, 2007
Cases: 353 (F:79; mean age: 42.7+9.7)
alcohol-dependent patients, including 102 suicide attempters, 58 of whom used violent means
Ethnicity-matched controls: 305 (F:141;mean age: 40.05+15.2)


Allelic: -,A, p=.0067 Genotypic: -, AA, p=.0033

Suicide attempts Ethnicity: Han Chinese, Shadong Ke, 2006
Cases: depressed suicide attempters: N: 102 (F: 61); mean age: 33.01 ±12.12
Controls: non-attempting depressed patients: N:123 (F:54);mean age: 33.26±14.36



Allelic : ns


Suicide attempts or suicidal behavior Cases: schizophrenic patients [n: 253 (F: 33%); mean age: 41±10.7] including 83 suicide attempters and 157 ideators/attempters) De Luca, 2005
hCV245410 Allelic : ns Notes: Used COCAPHAE and QTPHASE
Haplotypic: ns
hCV245410 Allelic: ns Suicide attempts or suicidal behavior Cases: Bipolar patients (including 86 suicide attempters and 267 ideators): n:336 (from 305 families): F:62%, mean age: 35±10 De Luca 2004
hCV8376173 Allelic: ns Notes: suicidality assessed on a quantitative scale from suicidal thoughts, through ideation, and plans, to suicide attempts
rs1487280 Allelic: ns
Haplotypic:: ns
14 SNPs Genotypic: +, rs4448731 (TT), OR 5.3 95% CI 1.7-16.4 Suicide Ethnicity: French Canadian Lopez de Lara, 2007
Cases: 259 depressed subjects, including 114 depressed suicides (F:16; mean age: 41.6±14.6)
Genotypic:+, rs4641527 (GG), OR 5.2 95% CI 1.7-16.0 Controls: 145 depressed nonsuicidal patients (F:21, mean age: 41.4±10.2)
Haplotypic: multiple Notes: alleles T, G, G, and C of SNPs rs4448731, rs6582071, rs4641527, and rs1386497, respectively, were overrepresented in depressed suicides, as were homozygotes for the T allele of rs4448731, the G allele of rs4641527, and carriers of the C allele of rs1386497. GG homozygotes for rs4641527 had lower reward dependence but there was no support for mediation by impulsive aggressive behaviors; Bonferroni-corrected



Suicide Cases: suicide completers (n:22; F:11) with schizophrenia (n:6) or bipolar disorder (n:16): mean age: 42.73±9.90


De Luca, 2006

8396GC Genotypic:ns Controls: individuals with schizophrenia (n: 29) and bipolar patients (n: 18) dying from non-suicide-related causes (F: 15): mean age: 44.98±9.37
Haplotypic: ns
10 SNPs Allelic: +, Rs1386494(G), p=.038 Suicide Ethnicity: Caucasian, Southern Germany Zill, 2004
Cases: suicide victims: F: 72; M: 191; mean age:47.1±18.1; 217 used violent means;
Healthy general population controls matched for ethnicity: M: 138, F:128; 39.7±15.3;
Notes: tested 10 SNPs; found 3 major haplotypes; haplotypic associations with suicide disappeared after Bonferoni correction

Haplotypic: ns

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males