SBGAS1

Adrenergic, alpha-2A-, receptor (ADRA2A)


Variant	Association	Phenotype	Notes	Author
rs3750625	Allelic: ns Genotypic: ns	Suicide	Ethnicity: Japanese	Fukutake, 2008
C1291G	Allelic:+,C, OR=1.96 CI95% 1.15-3.32, in females Genotypic:+, CG, p=.043, in females		Cases: suicide completers: M: 124 (mean age:49.2±16.9) and F: 60 (mean age: 45.7±19.0)
C1291G			Controls: M: 134 (mean age:41.9±16.1) and F:87 (mean age: 45.1±16.4)
	Haplotypic:: +, CC, p=.032, in females		Notes: N251K and insertion/deletion polymorphism not found in the sample; associations positive in female violent suicide attempts.
G1800T	Allelic: ns Genotypic: ns	Suicide	Ethnicity: French Canadian	Sequeira, 2004
C1291G	Allelic: ns Genotypic: ns		Cases:male suicide completers: [n:110, mean age: 32.20±9.38]
G261A	Allelic: ns Genotypic: ns		Male controls: n:130, mean age:34.00±10.56
N251K	Allelic: ns Genotypic: ns		Notes: N251K allele seen exclusively in suicides (n=3); Genotypes did not differ in impulsivity, aggressivity, or TCI temperament dimensions
C1291G	Allelic: ns Genotypic: ns	Suicide attempts	Ethnicity: Japanese	Ohara, 1998
			Cases: mood-disordered patients (F:55; M:48, including 11 suicide attempters
			Volunteer controls: F:62; M:52; mean age:37.7±15.9
			Notes: no association with mood disorders; Bonferroni-adjusted analyses

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Solute carrier family 6 (noradrenaline transporter) member 2 (SLC6A2)


Variant	Association	Phenotype	Notes	Author
G1287A	Allelic: ns Genotypic: ns	Suicidal ideas	Ethnicity: Caucasian	Owen, 1999
			Cases: mood-disordered patients: F:64, M:41; mean age: 39.5±8.94
			Race-matched controls without medical or psychtric illness: M:33, F:41; mean age: 34.8±10.7
			Notes: no asociation with major depression

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Tyrosine hydroxylase (TH)


Variant	Association	Phenotype	Sample Information	Author
rs3842727 rs6356	Allelic: ns Genotypic: ns Haplotypic: ns	Suicide and suicide attempts	Ethnicity: German	Giegling, 2008
			Cases: 167 suicide attempters (M:58, F:109; mean age, 39.89 ± 13.89; 60 patients classified as violent and 101 as impulsive)
			Cases: 92 Caucasian suicide completers (M:53, F:39; mean age 51.8 ± 18.5)
			Controls: unrelated German volunteers without personal or family histories of neuropsychiatric disorders (F:174, M: 138; mean age, 45.01 ± 14.92)
			Notes: excluded stratification using genomic control; no association with personality traits; stratified for violence, impulsiveness, and completions versus attempts
Intron 1 tetranucleotide repeat	Allelic: ns	Suicidal behaviour severity	Cases: 336 (F:62%;mean age: 35.36± 10.37 SD) bipolar patients from 305 nuclear families, including 267 patients with suicide ideas or attempts	De Luca, 2008
Intron 1 tetranucleotide repeat	Allelic: ns	Suicidal behaviour severity	Notes: suicidality assessed quantitatively and coded as follows: 0 = absence of suicide/death thoughts, 1 = thoughts of death, 2 = suicide ideation, 3 = suicide plan, 4 = suicide attempt; marginal association between TH & severe suicidal behaviour	De Luca, 2008
Val81Met Val468Met	Allelic: ns Genotypic: ns	Suicide	Ethnicity: Japanese	Hattori, 2006
			Cases: 189 suicide victims (F: 62, mean age ± SD, 47.9±17.6)
			Controls: 187 unrelated volunteers (F:61; mean age±SD, 44.7±14.9)
Promoter locus	Genotypic: ns	Suicide attempts	Ethnicity: English, Caucasian	Ho, 2000
			Cases: bipolar (M:58, F: 73 female) and unipolar patients (M:53, F: 86)
			Notes: in the unipolar sample, the promoter locus associated with psychotic symptoms; uncorrected for multiple testing
THK 1-5	Genotypic: +, THK3, p=.0023, patients with adjustment disorders	Suicide attempts	Ethnicity: Caucasian, mostly Swedish	Persson, 1997
			Cases: suicide attempters: F:76,M:42; mean age: 41
			Nonpsychiatric controls: F:33,M:45; mean age: 39
			Notes: Bonferroni corrected

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Catechol-O-methyltransferase (COMT)


Variant	Association	Phenotype	Notes	Author
COMT: allele Val158Met TPH1: allele A218C MAOA: allele u-VNTR male	Genotypic; s, COMT Met, p=.003 trait anger ; p=.041 anger out TPH1 A218C, p=.029 anger control MAOA u-VNTR, p=.041 state anger	Suicide Attempters	Ethnicity: Caucasian, French	Perroud, 2010
			Cases: 895 suicide attempters (F: 619; 39.6 ± 12.9)
			Notes: A significant correlation was found between sexual abuse and the Met allele, distinguishing it as the major epigenetic factor out of all other environmental variables

Val158Met	Allelic: ns Genotypic: ns	Mood disoders	Ethnicity: Caucasian	Zalsman, 2008
			Healthy volunteers: 119
			Mood disorders subject: 486
			Notes: CSF metabolites were assayed in a sub-sample of mood disorder patients (N=111)
			No association between genotype and mood disorder diagnosis or with reported history of suicide attempt in mood disorder subjects No association between genotype and lethality, or method of suicide attempt, or with aggressive/impulsive traits.
Val158Met	Allelic: ns	Suicidal behaviour severity	Cases: 336 (F:62%) bipolar patients from 305 nuclear families (mean age: 35.36± 10.37 SD), including 267 patients with histories of suicide ideas or attempts	De Luca, 2007
Val158Met	Allelic: ns	Suicidal behaviour severity	Notes: suicidality assessed a quantitatively and coded as follows: 0 = absence of suicide/death thoughts, 1 = thoughts of death, 2 = suicide ideation, 3 = suicide plan, 4 = suicide attempt	De Luca, 2007
287AG	Allelic: ns	Suicide attempts	Sample: schizophrenic patients (n:270): suicide attempters: 92 (F:24), mean age:42.6±9.7; nonattempters: mean age:40.6±11.2	De Luca, 2006
Val/Met	Allelic: ns		Notes: Investigated one MAO and three COMT variants; analyses also stratified by sex and violence of attempt method
3'UTR C Ins/Del	Allelic: ns
	Haplotypic: ns
	Epistatic interaction with MAO's uVNTR: ns
Val108/158Met	Allelic: ns	Suicide attempts	Sample: 336 bipolar patients (F:62%) including 86 suicide attempters; mean age:35.36±10.37	De Luca, 2005
	Allelic: ns		Notes: Analyses based on TDT; suicidality also assessed quantitatively
	Epistatic interaction with MAOA: ns
Val108/158Met	Allelic:+, L, OR 1.57, 95% CI 1.04-2.38, relative to controls	Violent suicide attempts	Ethnicity: German	Rujescu, 2003
	Allelic:+, L, OR 1.7, 95% CI 1.07-2.79, relative to nonviolent attempters		Suicide attempters: F:96, M:53; mean age:40±13; violent attempters:55]
	Genotypic: +, LL, OR=2.12, 95% CI 1.18-3.83, relative to controls		Community controls: F:179,M:149; mean age: 46±15]
	Genotypic: +, LL, OR=2.35, 95% CI 1.15-4.82, relative to nonviolent attempters		Notes: LL carriers expressed anger outwardly and HH carriers more inwardly, controlling for age and sex
Val158Met	Allelic: ns Genotypic: ns	Suicide attempts	Ethnicity: Chinese, Taiwan;	Liou, 2001
			Cases: schizophrenic patients [F:104,M:94; mean age: 37.8±12.1], including 62 suicide attempters
			Healthy volunteer controls: F:91,M:97; mean age: 38.6±16.6
			Notes: not associated with schizophrenia with or without violence
Val108/158Met	Allelic:+,Met, p=.05, men Genotypic: +, Met-, p=.017, men	Violent suicide attempts	Ethnicity: Finnish nonSaami sample: n:94 (F:10, mean age: 41.8, 57 suicide attempters) and USA sample (White, 4 Hispanic): n: 54 (F:21, mean age: 42.9, 27 suicide attempters)	Nolan, 2000
	Allelic:+,Met, p=.05, men Genotypic: +, Met-, p=.017, men	Violent suicide attempts	Cases: schizophrenic/ schizoaffective attempters and nonattempters
	Allelic:+, Met, p=.008, men Genotypic: +, Met-, p=.028, men	Suicide attempts	Notes: association found in the combined samples and in the Finnish sample on its own
L/H	Allelic: ns Genotypic: ns	Suicide attempts	Ethnicity: Japanese	Ohara, 1998
			Cases: 12 mood-disordered patients [M:60, F:55; suicide attempters; mean age:48.5±16.3]
			Healthy controls: N:135
			Notes: positive association of LL genotype with depressive disorders [p=.012, OR=2.19; 95%CI 1.19-4.03]
Val108/158Met	Allelic: ns Genotypic: -,Val/Val, OR .52 95% .31-.89, males Genotypic: +,Val/Met, OR 1.98 95% 1.16-3.37, males	Suicide	Cases: suicide completers: M:112; mean age:48.68±16.9; F:51; mean age: 47.12±19.8	Ono, 2004
			Controls: M:114; mean age:45.33±15.5; F:55; mean age: 48.9±18.7
			Notes: trend toward deviation from HW equilibrium in male completers
Val108/158Met	Genotypic: ns	Suicide risk	Cases: patients at high risk for suicide: F:32,M:19; mean age:38±15; Caucasian (n:41), African-American (n:6), and Hispanic, Indian, and Asian (n:4)	Russ, 2000
			Race-matched controls: F:28,M:23; mean age:41±13
			Notes:Bonferroni corrected

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Monoamino oxidase A (MAOA)


Variant	Association	Phenotype	Sample Information	Author
uVNTR	Allelic: ns Epistasis with COMT: ns	Suicide attempts	Cases: 270 schizophrenic patients: 92 (F:24) suicide attempters (mean age: 42.6±9.7) and 178 nonattempters (mean age: 40.6±11.2)	De Luca, 2006
uVNTR	Allelic: ns Epistasis with COMT: ns	Suicide attempts	Notes: Investigated one MAO and three COMT; also stratified by sex and violence of suicide attempt	De Luca, 2006
uVNTR	Allelic: ns Genotypic: +,2-3 alleles, OR: 2.17 95% CI 1.08-4.35, males	Violent suicide attempts	Ethnicity: West European, Caucasian	Courtet, 2005
uVNTR		Violent suicide attempts	Hospitalized suicide attempters: F:512; M:226; mean age: 38.08 ± 14.12
CAn	Allelic: ns	Suicide attempts	Non-psychiatric controls without first-degree family history of suicide attempts: F:68, M:154; mean age: 44.25±13.26
CAn	Allelic: ns	Suicide attempts	Notes: CAn is in LD with uVNTR
uVNTR T941G	Allelic: ns Haplotypic: ns Epistasis with COMT: ns	Suicide attempts	Sample: 336 bipolar patients (F:62%) including 86 suicide attempters; mean age:35.36±10.37	De Luca, 2005
uVNTR T941G	Allelic: ns Haplotypic: ns Epistasis with COMT: ns	Suicide attempts	Notes: analyses based on TDT; No epistasis with COMT Val108/158 Met	De Luca, 2005
uVNTR	Allelic: ns	Suicide attempts	Ethnicity: white Caucasian, Italian	Gerra, 2004
			Heroin –dependent males: n:104; mean age: 33.7±12.3
			Age- and sex-matched healthy volunteers: n:95; mean age: 35.7±13.9
			Notes: this variant confers increased susceptibility to antisocial violent behavior and aggressiveness in heroin-dependent males
uVNTR	Allelic: ns Genotypic: ns	Suicide attempts	Cases: mood-disordered patients: F:377, M:286; mean age: 37.6 ±12.9; Caucasian: 68.8%; African-Americans 16.6%; Asian, Hispanic and ‘’other" 14.6%	Huang, 2004
			Nonpsychiatric controls with comparable ethnic composition: F:47, M:56; mean age: 38.8 ±15.3
			Notes: lower expression allele associated with history of child abuse before 15 years of age and higher impulsivity in males
CAn	ns	Suicide attempts	Ethnicity: English, Caucasian	Ho, 2000
VNTR	Genotypic: +, VNTR, ,p=0.029, bipolar patients		Cases: bipolar (M:58, F: 73) and unipolar patients (M:53, F: 86)
Fnu4HI	Genotypic:+, 11, p=0.0162, female bipolar patients		Notes: VNTR’s association with suicide attempts stronger in females; uncorrected for multiple testing
VNTR	Allelic: ns Genotypic: ns	Suicide attempts	Ethnicity: Japanese	Kunugi, 1999
			Patients with bipolar disorder (M:59, F:102; mean age: 47.6±13.7) or unipolar (F:61, M:37; mean age: 54.5±16.4), including 55 suicide attempters
			Controls: M:132; F:126 mean age: 31.8.6±12.3
			Notes: no association with mood disorders
EcoRV	Allelic: +,high-activity allele, OR:3.1, 95% CI 1.3-7.5, males	Suicide	Ethnicity: Caucasian, Hungary	Du, 2002
			Depressed suicide completers: F:11; M:33 mean age: 47.9±14.4
			Controls who died of non-suicide-related causes: F:28; M:64 mean age: 57.5±13.6
			Notes: Bonferroni-corrected
uVNTR	Allelic: ns Genotypic: ns	Suicide	Ethnicity: Japanese	Ono, 2002
			Cases: suicides [M: 107; mean age: 48.4 ±16.6; F: 48; mean age: 47.6± 19.9]
			Healthy volunteers [M: 109; mean age: 45.1± 15.3; F: 53; mean age: 48.4±18.8]

Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=males

Last Updated: December, 2008