Corticotrophin-releasing hormone (CRH)
Variant | Association | Phenotype | Sample Information | Author |
rs1870393 rs3176921 |
Allelic: ns |
Suicide attempts | Ethnicity: Caucasian and Ukrainian |
|
Analyses conducted in a. screening sample (272 family trios with offspring had suicidal history); b. replication sample (270 family trios; age of offspring 24.0±7.2; F: 48.9%; 26.7% attempted suicide) |
Notes: Bonferroni-corrected |
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Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=Males
Corticotrophin-releasing hormone receptor 1 (CRHR1)
Variant | Association | Phenotype | Sample Information | Author |
RS110402 rs242937 |
Allelic: ns Genotypic: ns |
Suicide attempts | Origin: Spanish | Papiol, 2007 | Cases: 159 depressive patients (F:124; mean age: 39.5±12.2), including 24 suicide attempters | Controls: 96 (F:41; mean age: 35.1±10.3) individuals without mental illness | Notes: also examined CRHR2, CRH-BP, FKBP5; CRHR1 (RS110402) linked to depressive disorder characteristics & CRHR2 (rs2270007) to citalopram response |
rs4792887
|
Alelic: +, T, p= 0.002, individuals exposed to low stress levels |
Suicide attempts | Ethnicity: Caucasian and Ukrainian |
|
Analyses conducted in a. screening sample (272 family trios whose offspring had suicidal history); b. replication sample (270 family trios; age of offspring 24.0±7.2; F: 48.9%; 26.7% attempted suicide) |
rs1396862 | Alelic: ns | Notes: rs4792887 association especially strong in depressed men (P= 0.001); Bonferroni-corrected |
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Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=Males
Corticotrophin-releasing hormone receptor 2 (CRHR2)Variant | Association | Phenotype | Notes | Author |
rs2270007 rs2240403 |
Allelic: ns Genotypic: ns |
Suicide attempts | Origin: Spanish | Papiol, 2007 | Cases: 159 depressive patients (F:124; mean age: 39.5±12.2), including 24 suicide attempters | Controls: 96 (F:41; mean age:35.1±10.3) individuals without mental illness | Notes: also examined CRHR1, CRH-BP, FKBP5; CRHR1 (rs110402) linked to depressive disorder characteristics and CRHR2 (rs2270007) to citalopram response. | (CA)n |
Allelic: ns | Severity of suicidal behavior
|
Cases: 194 females and 118 males with bipolar disorder from 312 nuclear families (mean age: 35.36± 10.37 SD), including 267 patients with histories of suicide ideas or attempts | (GT)n | Allelic: +, 3, p = 0.027 | (GAT)n | Allelic: ns | Notes: overall associations of single markers and haplotypes are negative and only post hoc tests appear to be significant; authors report association with bipolar disorder; suicidality assessed quantitatively and coded as follows: 0 = absence of suicide/death thoughts, 1 = thoughts of death, 2 = suicide ideation,3 = suicide plan, 4 = suicide attempt |
Haplotypic: +, 5-2-3, p=.004 |
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Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=Males
CRH binding protein (CRH-BP)Variant | Association | Phenotype | Notes | Author | rs7728378 rs1875999 |
Allelic: ns Genotypic: ns |
Suicide attempts | Origin: Spanish | Papiol, 2007 | Cases: 159 depressive patients (F:124; mean age: 39.5±12.2), including 24 suicide attempters | Controls: 96 (F:41; mean age:35.1±10.3) individuals without mental illness | Notes: also examined CRHR1, CRHR2, FKBP5; CRHR1 (rs110402) linked to depressive disorder characteristics and CRHR2 (rs2270007) to citalopram response |
---|
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=Males
FK506 binding protein 5(FKBP5)
Variant | Association | Phenotype | Notes | Author |
---|---|---|---|---|
rs1360780 rs3800373 | Genotypic: s rs1360780TT rs3800373GG p=0.025 | suicidal behavior in adolescents participating in the Treatment of SSRI-Resistant Depression in Adolescents (TORDIA) | Origin: European | Brent, 2009 |
Patients: 155 depressed adolescents participating in the Treatment of SSRI-Resistant Depression |
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Notes: Also investigated
DAT1 DAT1 40-bp VNTR |
rs1360780 |
Allelic: ns Genotypic: ns |
Suicide attempts | Origin: Spanish | Papiol, 2007 | Cases: 159 depressive patients (F:124; mean age: 39.5±12.2), including 24 suicide attempters | Controls: 96 (F:41; mean age: 35.1±10.3) individuals without mental illness | Notes: also examined CRHR1, CRHR2, CRH-BP; CRHR1 (rs110402) linked to depressive disorder characteristics and CRHR2 (rs2270007) to citalopram response |
Notes: += positive,significant; - =negative,significant; ns= nonsignificant; F=females; M=Males